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49ers vs. Eagles prediction: Why Philadelphia is favored to win Wild Card game [2026]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get San Francisco 49ers vs Philadelphia Eagles predictions for NFL Sunday.
The Philadelphia Eagles will face the San Francisco 49ers on Wild Card weekend of the NFL Playoffs at Lincoln Financial Field on Sunday, commencing at 4:30 PM ET.
Based on the latest simulation results, Dimers' proven NFL model projects the Eagles as the most likely winner of the 49ers vs. Eagles game.
This article offers an expanded analysis of Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.
Niners vs. Eagles prediction: Who will win and cover?
Since our 49ers-Eagles predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the 49ers and Eagles 10,000 times as part of our NFL predictions coverage.
Our famous predictive model gives the Eagles a 68% chance of beating the 49ers. Our predicted final score has the Eagles winning 24-19.
According to our model, the 49ers (+5.5) have a 54% chance of covering the spread, while the over/under total of 44.5 points has an equal 50-50 chance of hitting.
To see win probabilities for every matchup this week, check out our expert NFL Week 19 straight up picks.
49ers vs. Eagles odds
We have sourced the best NFL odds in America for this game, which are listed here:
| Bet Type | 49ers | Eagles |
|---|---|---|
| Spread | +5.5 (-110) | -5.5 (-110) |
| Moneyline | +215 | -250 |
| Total | o44.5 (-105) | u44.5 (-110) |
All odds are correct at the time of publication and are subject to change.
49ers vs. Eagles picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | 49ers +5.5 | -110 |
| Moneyline | 49ers | +215 |
| Total | Over 44.5 | -105 |
According to our NFL best bets, the top play to make on this game is 49ers +5.5 at the spread.
49ers vs. Eagles TD scorers
Who will score a touchdown in 49ers vs. Eagles?
According to our list of touchdown scorer predictions for Week 19, Christian McCaffrey is most likely to score an anytime touchdown in 49ers vs. Eagles.
Our projections give McCaffrey a 57.8% chance of scoring a TD at Lincoln Financial Field, while the running back is a 14.4% chance of scoring the first touchdown the game.
Anytime touchdown scorer predictions
San Francisco 49ers
| Player | Anytime TD Probability |
|---|---|
| Christian McCaffrey (RB) | 57.8% |
| George Kittle (TE) | 34.1% |
| Jauan Jennings (WR) | 30.8% |
| Demarcus Robinson (WR) | 16.9% |
| Brock Purdy (QB) | 15.3% |
Philadelphia Eagles
| Player | Anytime TD Probability |
|---|---|
| Saquon Barkley (RB) | 48.0% |
| Jalen Hurts (QB) | 41.9% |
| A.J. Brown (WR) | 36.6% |
| Dallas Goedert (TE) | 32.9% |
| DeVonta Smith (WR) | 31.2% |
First touchdown scorer predictions
San Francisco 49ers
| Player | First TD Probability |
|---|---|
| Christian McCaffrey (RB) | 14.4% |
| George Kittle (TE) | 7.0% |
| Jauan Jennings (WR) | 6.2% |
| Demarcus Robinson (WR) | 3.1% |
| Brock Purdy (QB) | 2.8% |
Philadelphia Eagles
| Player | First TD Probability |
|---|---|
| Saquon Barkley (RB) | 12.1% |
| Jalen Hurts (QB) | 10.0% |
| A.J. Brown (WR) | 8.4% |
| Dallas Goedert (TE) | 7.4% |
| DeVonta Smith (WR) | 6.9% |
49ers vs Eagles player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Eagles. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 19 games.
Quarterbacks
Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 228 passing yards, while the Eagles' Jalen Hurts is expected to throw for 214 yards.
| Player | Proj. Pass Yards |
|---|---|
| Brock Purdy (SF) | 228 |
| Jalen Hurts (PHI) | 214 |
49ers rushing
| Player | Proj. Rush Yards |
|---|---|
| Christian McCaffrey | 69 |
| Brock Purdy | 21 |
| Brian Robinson | 17 |
Eagles rushing
| Player | Proj. Rush Yards |
|---|---|
| Saquon Barkley | 81 |
| Jalen Hurts | 33 |
| Tank Bigsby | 12 |
49ers receiving
| Player | Proj. Rec. Yards |
|---|---|
| George Kittle | 58 |
| Jauan Jennings | 50 |
| Christian McCaffrey | 44 |
| Demarcus Robinson | 28 |
| Kendrick Bourne | 22 |
Eagles receiving
| Player | Proj. Rec. Yards |
|---|---|
| A.J. Brown | 71 |
| DeVonta Smith | 59 |
| Dallas Goedert | 42 |
| Saquon Barkley | 19 |
| Jahan Dotson | 15 |
Niners vs. Eagles game-day updates and essential details
Sunday's matchup between the Eagles and 49ers at Lincoln Financial Field is scheduled to start at 4:30 PM ET.
- Who: San Francisco 49ers vs. Philadelphia Eagles
- Date: Sunday, January 11, 2026
- Time: 4:30 PM ET/1:30PM PT
- Venue: Lincoln Financial Field
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Conclusion
We predict the Eagles, with a 68% win probability, will likely beat the 49ers on Sunday.
AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Eagles insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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