49ers vs. Giants prediction: San Francisco favored to win in NFL Week 9, 2025

The New York Giants and San Francisco 49ers are scheduled to meet in Week 9 of the NFL season at MetLife Stadium on Sunday, with kickoff at 1:00PM ET.

Based on updated simulation results, Dimers' proven NFL model predicts the 49ers as the most likely winner of the 49ers vs. Giants game.

This article offers an expanded analysis of this week's matchup, including touchdown scorer projections, best bets and player prop picks.

Niners vs. Giants prediction: Who will win, cover the spread?

Since our 49ers-Giants predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the 49ers and Giants 10,000 times as part of our NFL predictions coverage.

Our famous predictive model currently gives the 49ers a 59% chance of beating the Giants in Week 9 of the NFL season. Our predicted final score has the 49ers winning 24-22.

According to our model, the bookmakers have got it right, and the 49ers and Giants each have a 50% chance of covering the spread, while the 47.5-point over/under also has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 9 straight up picks.

49ers vs. Giants odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	49ers	Giants
Spread	-2.5 (-110)	+2.5 (+100)
Moneyline	-138	+124
Total	o47.5 (-110)	u47.5 (-105)

All odds are correct at the time of publication and are subject to change.

49ers vs. Giants picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Giants +2.5	+100
Moneyline	49ers	-138
Total	Under 47.5	-105

According to our NFL best bets, the top play to make on this game is 49ers to win.

49ers vs. Giants TD scorers

Who will score a touchdown in 49ers vs. Giants?

According to our list of touchdown scorer predictions for today, Christian McCaffrey is most likely to score an anytime TD in 49ers vs. Giants.

Our projections give McCaffrey a 63.2% chance of getting in for six at MetLife Stadium, while the running back is a 17.4% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

San Francisco 49ers

Player	Anytime TD Probability
Christian McCaffrey (RB)	63.2%
George Kittle (TE)	38.8%
Jauan Jennings (WR)	29.7%
Kendrick Bourne (WR)	21.8%
Demarcus Robinson (WR)	14.0%

New York Giants

Player	Anytime TD Probability
Tyrone Tracy (RB)	39.2%
Wan'Dale Robinson (WR)	32.7%
Theo Johnson (TE)	28.7%
Jaxson Dart (QB)	27.7%
Darius Slayton (WR)	26.0%

First touchdown scorer predictions

San Francisco 49ers

Player	First TD Probability
Christian McCaffrey (RB)	17.4%
George Kittle (TE)	8.5%
Jauan Jennings (WR)	6.1%
Kendrick Bourne (WR)	4.3%
Demarcus Robinson (WR)	2.6%

New York Giants

Player	First TD Probability
Tyrone Tracy (RB)	8.9%
Wan'Dale Robinson (WR)	7.1%
Theo Johnson (TE)	6.1%
Jaxson Dart (QB)	5.8%
Darius Slayton (WR)	5.4%

49ers vs Giants player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Giants. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 9 games.

Quarterbacks

Of the starting quarterbacks, the 49ers' Mac Jones is projected for 245 passing yards. The Giants' Jaxson Dart is expected to throw for 216 yards.

Player	Proj. Pass Yards
Mac Jones (SF)	245
Jaxson Dart (NYG)	216

49ers rushing

Player	Proj. Rush Yards
Christian McCaffrey	84
Brian Robinson	19
Mac Jones	10

Giants rushing

Player	Proj. Rush Yards
Tyrone Tracy	54
Jaxson Dart	35
Devin Singletary	20

49ers receiving

Player	Proj. Rec. Yards
Jauan Jennings	55
George Kittle	52
Christian McCaffrey	49
Kendrick Bourne	43
Demarcus Robinson	24

Giants receiving

Player	Proj. Rec. Yards
Wan'Dale Robinson	58
Darius Slayton	45
Theo Johnson	39
Tyrone Tracy	22
Ray-Ray McCloud	21

Niners vs. Giants game-day updates and essential details

The NFL Week 9 matchup between the Giants and 49ers at MetLife Stadium is scheduled to begin at 1:00PM ET.

• Who: San Francisco 49ers vs. New York Giants
• Date: Sunday, November 2, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: MetLife Stadium

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Conclusion

We predict the 49ers, with a 59% win probability, will likely beat the Giants in Week 9 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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