San Francisco 49ers vs. Houston Texans: Experts release early Week 8 predictions [2025]

The San Francisco 49ers and Houston Texans will meet in Week 8 of the NFL season at NRG Stadium on Sunday, October 26, 2025, starting at 1:00PM ET.

Early simulations from Dimers' trusted NFL model favor the 49ers as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive 49ers vs. Texans predictions page.

San Francisco vs. Houston early predictions

Leveraging trusted machine learning and analysis, we have simulated the Niners vs. Texans game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: 49ers 59%, Texans 41%
• Predicted final score: 49ers 23-20 Texans
• Spread: 49ers (-1.5) 53%, Texans (+1.5) 47%
• Total points (45.5): Over 43%, Under 57%

As of October 19, 2025, these 49ers-Texans calculations and predictions reflect the latest data and insights available.

Niners vs. Texans Week 8 details

The NFL Week 8 action between the Texans and 49ers at NRG Stadium is scheduled for October 26, 2025.

• Who: San Francisco 49ers vs. Houston Texans
• Date: Sunday, October 26, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: NRG Stadium

Niners vs. Texans opening odds

We've researched the best betting odds across America for this Week 8 game, which are listed here:

• Spread: 49ers -1.5 (-108), Texans +1.5 (-112)
• Moneyline: 49ers -125, Texans +105
• Total: Over/Under 45.5 (-115/-105)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the 49ers, with a 59% win probability, will likely beat the Texans in Week 8 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Texans game, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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