49ers vs. Browns prediction: Why San Francisco is favored to win in NFL Week 13, 2025

The Cleveland Browns will face the favored San Francisco 49ers in NFL Week 13 action at Huntington Bank Field on Sunday, starting at 1:00PM ET.

Based on updated simulations, Dimers' proven NFL model predicts the 49ers as the most likely winner of the 49ers vs. Browns game.

This article offers further insights into Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.

Niners vs. Browns prediction: Who will win and cover?

Since our 49ers-Browns predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the 49ers and Browns 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the 49ers a 74% chance of beating the Browns in Week 13 of the NFL season. Our predicted final score has the 49ers winning 20-15.

According to our model, the bookmakers have got it right, and the 49ers and Browns each have a 50% chance of covering the spread, while the over/under total of 35.5 points has a 53% chance of going over.

To see win probabilities for every matchup this week, check out our expert NFL Week 13 straight up picks.

49ers vs. Browns odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type	49ers	Browns
Spread	-5.5 (-102)	+5.5 (-110)
Moneyline	-250	+205
Total	o35.5 (-104)	u35.5 (-112)

All odds are correct at the time of publication and are subject to change.

49ers vs. Browns picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	49ers -5.5	-102
Moneyline	49ers	-250
Total	Over 35.5	-104

According to our NFL best bets, the top play to make on this game is 49ers to win.

49ers vs. Browns TD scorers

Who will score a touchdown in 49ers vs. Browns?

According to our list of touchdown scorer predictions for today, Christian McCaffrey is most likely to score an anytime touchdown in 49ers vs. Browns.

Our projections give McCaffrey a 56.5% chance of scoring a TD at Huntington Bank Field, while the running back is a 19.2% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

San Francisco 49ers

Player	Anytime TD Probability
Christian McCaffrey (RB)	56.5%
George Kittle (TE)	31.4%
Jauan Jennings (WR)	25.6%
Ricky Pearsall (WR)	19.2%
Brian Robinson (RB)	12.7%

Cleveland Browns

Player	Anytime TD Probability
Quinshon Judkins (RB)	44.3%
Harold Fannin (TE)	19.4%
Cedric Tillman (WR)	17.2%
Dylan Sampson (RB)	14.7%
Jerry Jeudy (WR)	14.7%

First touchdown scorer predictions

San Francisco 49ers

Player	First TD Probability
Christian McCaffrey (RB)	19.2%
George Kittle (TE)	8.7%
Jauan Jennings (WR)	6.8%
Ricky Pearsall (WR)	4.9%
Brian Robinson (RB)	3.1%

Cleveland Browns

Player	First TD Probability
Quinshon Judkins (RB)	12.5%
Harold Fannin (TE)	4.6%
Cedric Tillman (WR)	4.0%
Dylan Sampson (RB)	3.4%
Jerry Jeudy (WR)	3.4%

49ers vs Browns player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Browns. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 13 games.

Quarterbacks

Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 197 passing yards. The Browns' Shedeur Sanders is expected to throw for just 157 yards.

Player	Proj. Pass Yards
Brock Purdy (SF)	197
Shedeur Sanders (CLE)	157

49ers rushing

Player	Proj. Rush Yards
Christian McCaffrey	71
Brian Robinson	26
Brock Purdy	15

Browns rushing

Player	Proj. Rush Yards
Quinshon Judkins	67
Dylan Sampson	15
Shedeur Sanders	12

49ers receiving

Player	Proj. Rec. Yards
George Kittle	45
Jauan Jennings	41
Christian McCaffrey	40
Ricky Pearsall	33
Demarcus Robinson	14

Browns receiving

Player	Proj. Rec. Yards
Harold Fannin	36
Jerry Jeudy	32
Cedric Tillman	24
David Njoku	19
Isaiah Bond	13

Niners vs. Browns game-day updates and essential details

The NFL Week 13 game between the Browns and 49ers at Huntington Bank Field is scheduled to start at 1:00PM ET.

• Who: San Francisco 49ers vs. Cleveland Browns
• Date: Sunday, November 30, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Huntington Bank Field

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Conclusion

We predict the 49ers, with a 74% win probability, will likely beat the Browns in Week 13 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Browns insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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