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Trail Blazers vs. Cavaliers prediction: Cleveland to win, Donovan Mitchell projected for big game in Wednesday's NBA matchup [12/3/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Portland Trail Blazers vs Cleveland Cavaliers predictions for NBA Wednesday.
The Cleveland Cavaliers will face the Portland Trail Blazers in NBA action at Rocket Arena on Wednesday, beginning at 7:00PM ET.
Based on the latest simulations and today’s injury news, Dimers' proven NBA model predicts the Cavaliers as the most likely winner of the Trail Blazers vs. Cavaliers game.
This prediction follows the latest NBA Injury Report, which suggests the Cavaliers lineup will feature stars like Donovan Mitchell, Darius Garland and Evan Mobley, while the Trail Blazers will look to Deni Avdija, Jerami Grant and Shaedon Sharpe.
This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Blazers vs. Cavs prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's NBA matchup between the Trail Blazers and Cavaliers 10,000 times as part of our NBA predictions coverage.
Our famous predictive model currently gives the Cavaliers a 78% chance of defeating the Trail Blazers. Our predicted final score has the Cavaliers winning 125-116.
According to our model, the Trail Blazers (+10) have a 55% chance of covering the spread, while the over/under total of 244.5 points has a 57% chance of staying under.
Trail Blazers vs. Cavaliers odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | Trail Blazers | Cavaliers |
|---|---|---|
| Spread | +10 (-106) | -10 (-114) |
| Moneyline | +370 | -450 |
| Total | o244.5 (-105) | u244.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Trail Blazers vs. Cavaliers picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Trail Blazers +10 | -106 |
| Moneyline | Trail Blazers | +370 |
| Total | Under 244.5 | -110 |
According to our best NBA bets for Wednesday, the top play to make on this game is Under 244.5 total points.
Trail Blazers vs. Cavaliers player props
Looking for Trail Blazers vs. Cavaliers NBA prop bets? We have crunched the numbers to project how each team's leading players will perform at Rocket Arena.
Deni Avdija is expected to lead the Trail Blazers with 26 points, 8 rebounds and 6 assists, while Donovan Mitchell is projected to have 28 points, 5 rebounds and 6 assists for the Cavaliers.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.
Trail Blazers prediction
Our model's projected player stats for the Trail Blazers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Deni Avdija | 26 | 8 | 6 | 3 | 51 |
| Jerami Grant | 19 | 4 | 3 | 3 | 34 |
| Shaedon Sharpe | 18 | 4 | 3 | 2 | 31 |
| Toumani Camara | 15 | 6 | 3 | 3 | 33 |
| Donovan Clingan | 9 | 10 | 2 | 1 | 30 |
Cavaliers prediction
Projected points, rebounds, assists and three-pointers made for the Cavaliers:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| D. Mitchell | 28 | 5 | 6 | 3 | 50 |
| Darius Garland | 20 | 3 | 6 | 3 | 39 |
| Evan Mobley | 19 | 9 | 4 | 2 | 45 |
| De'Andre Hunter | 16 | 5 | 2 | 2 | 30 |
| Jaylon Tyson | 13 | 6 | 3 | 2 | 29 |
Blazers vs. Cavs game-day updates and essential details
Wednesday's action between the Cavaliers and Trail Blazers at Rocket Arena is scheduled to start at 7:00PM ET.
- Who: Portland Trail Blazers vs. Cleveland Cavaliers
- Date: Wednesday, December 3, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: Rocket Arena
Conclusion
We predict the Cavaliers, with a 78% win probability, will likely beat the Trail Blazers on Wednesday, with Deni Avdija projected for a game-high 51 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Trail Blazers vs. Cavaliers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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