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76ers vs. Knicks prediction: New York to win, Jalen Brunson projected for big game in Friday's NBA matchup [12/19/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Philadelphia 76ers vs New York Knicks predictions for NBA Friday.
The New York Knicks and Philadelphia sixers are scheduled to meet in NBA action at Madison Square Garden on Friday, with tipoff at 7:00 PM ET.
Based on the latest simulation results and today’s injury reports, Dimers' advanced NBA model predicts the Knicks as the most likely winner of the 76ers vs. Knicks game.
This prediction follows the latest NBA Injury Report, which suggests the Knicks lineup will feature stars like Jalen Brunson, Karl-Anthony Towns and OG Anunoby, while the 76ers will be led by Tyrese Maxey, Joel Embiid and Paul George.
This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Sixers vs. Sixers prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the outcome of Friday's NBA matchup between the 76ers and Knicks 10,000 times as part of our NBA predictions coverage.
Our famous predictive model currently gives the Knicks a 63% chance of defeating the 76ers. Our predicted final score has the Knicks winning 116-112.
According to our model, the Knicks (-4.5) have a 51% chance of covering the spread, while the over/under total of 228.5 points has a 51% chance of going over.
76ers vs. Knicks odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | 76ers | Knicks |
|---|---|---|
| Spread | +4.5 (-112) | -4.5 (-108) |
| Moneyline | +150 | -174 |
| Total | o228.5 (-105) | u228.5 (-110) |
All odds are correct at the time of publication and are subject to change.
76ers vs. Knicks picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Knicks -4.5 | -108 |
| Moneyline | Knicks | -174 |
| Total | Over 228.5 | -105 |
According to our best NBA bets for Friday, the top play to make on this game is Knicks to win.
76ers vs. Knicks player props
NBA player props are a common way to wager on the 76ers vs. Knicks game without necessarily betting on the outcome. We use the best information available to project how each team's leading players will perform at Madison Square Garden.
Tyrese Maxey is expected to lead the 76ers with 26 points, 4 rebounds and 7 assists, while Jalen Brunson is projected to have 28 points, 3 rebounds and 7 assists for the Knicks.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
76ers prediction
Our model's projected player stats for the 76ers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Tyrese Maxey | 26 | 4 | 7 | 3 | 47 |
| Joel Embiid | 21 | 7 | 3 | 2 | 41 |
| Paul George | 18 | 6 | 4 | 3 | 37 |
| Quentin Grimes | 17 | 5 | 5 | 3 | 37 |
| VJ Edgecombe | 15 | 6 | 4 | 2 | 33 |
Knicks prediction
Projected points, rebounds, assists and three-pointers made for the Knicks:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Jalen Brunson | 28 | 3 | 7 | 3 | 47 |
| K. Towns | 23 | 11 | 2 | 3 | 45 |
| OG Anunoby | 18 | 5 | 2 | 2 | 34 |
| Mikal Bridges | 16 | 5 | 4 | 2 | 34 |
| Jordan Clarkson | 12 | 2 | 3 | 2 | 23 |
Sixers vs. Knicks game-day updates and essential details
Friday's action between the Knicks and 76ers at Madison Square Garden is scheduled to commence at 7:00 PM ET.
- Who: Philadelphia 76ers vs. New York Knicks
- Date: Friday, December 19, 2025
- Time: 7:00 PM ET/4:00PM PT
- Venue: Madison Square Garden
Conclusion
We predict the Knicks, with a 63% win probability, will likely beat the 76ers on Friday, with Jalen Brunson projected for a game-high 47 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate 76ers vs. Knicks insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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