76ers vs. Knicks prediction: New York to win, Jalen Brunson projected for big game in Friday's NBA matchup [12/19/2025]

The New York Knicks and Philadelphia sixers will meet in NBA action at Madison Square Garden on Friday, starting at 7:00 PM ET.

Based on updated simulations and today’s injury reports, Dimers' advanced NBA model projects the Knicks as the most likely winner of the 76ers vs. Knicks game.

This prediction follows the latest NBA Injury Report, which suggests the Knicks lineup will feature players like Jalen Brunson, Karl-Anthony Towns and OG Anunoby, while the 76ers will look to Tyrese Maxey, Paul George and Quentin Grimes.

This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Sixers vs. Sixers prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Friday's NBA game between the 76ers and Knicks 10,000 times as part of our NBA predictions coverage.

Our famous predictive model gives the Knicks a 70% chance of beating the 76ers. Our predicted final score has the Knicks winning 118-112.

According to our model, the 76ers (+6.5) have a 53% chance of covering the spread, while the 230.5-point over/under has an equal 50-50 chance of hitting.

76ers vs. Knicks odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

76ers vs. Knicks picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Friday, the top play to make on this game is 76ers +6.5 at the spread.

76ers vs. Knicks player props

NBA prop bets are an exciting way to wager on the Philadelphia vs. New York game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Madison Square Garden.

Tyrese Maxey is expected to lead the 76ers with 27 points, 4 rebounds and 7 assists, while Jalen Brunson is projected to have 28 points, 3 rebounds and 7 assists for the Knicks.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

76ers prediction

Our model's projected player stats for the 76ers are:

Knicks prediction

Projected points, rebounds, assists and three-pointers made for the Knicks:

Sixers vs. Knicks game-day updates and essential details

Friday's matchup between the Knicks and 76ers at Madison Square Garden is scheduled to commence at 7:00 PM ET.

• Who: Philadelphia 76ers vs. New York Knicks
• Date: Friday, December 19, 2025
• Time: 7:00 PM ET/4:00PM PT
• Venue: Madison Square Garden

Conclusion

We predict the Knicks, with a 70% win probability, will likely beat the 76ers on Friday, with Tyrese Maxey projected for a game-high 48 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate 76ers vs. Knicks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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