76ers vs. Pelicans prediction: Philadelphia favored to win Saturday's NBA matchup [2/21/2026]

NBA action continues on Saturday at 7:00 PM ET as the Philadelphia 76ers take on the New Orleans Pelicans at Smoothie King Center.

Based on updated simulations and today’s injury news, Dimers' advanced NBA model predicts the 76ers as the most likely winner of the 76ers vs. Pelicans game.

This prediction follows the latest NBA Injury Report, which suggests the Pelicans lineup will feature stars like Zion Williamson, Saddiq Bey and Jeremiah Fears, while the 76ers will rely on Tyrese Maxey, Kelly Oubre and VJ Edgecombe.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Sixers vs. Sixers prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Saturday's NBA game between the 76ers and Pelicans 10,000 times as part of our NBA predictions coverage.

Our leading predictive model currently gives the 76ers a 60% chance of defeating the Pelicans. Our predicted final score has the 76ers winning 118-116.

According to our model, the Pelicans (+3.5) have a 52% chance of covering the spread, while the over/under total of 235.5 points has a 51% chance of staying under.

76ers vs. Pelicans odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

76ers vs. Pelicans picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Saturday, the top play to make on this game is Pelicans +3.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

76ers vs. Pelicans player props

NBA prop bets are a great way to wager on Saturday's Philadelphia vs. New Orleans matchup without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Smoothie King Center.

Tyrese Maxey is expected to lead the 76ers with 30 points, 4 rebounds and 7 assists, while Zion Williamson is projected to have 23 points, 6 rebounds and 4 assists for the Pelicans.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

76ers prediction

Our model's projected player stats for the 76ers are:

Pelicans prediction

Projected points, rebounds, assists and three-pointers made for the Pelicans:

Sixers vs. Pelicans game-day updates and essential details

Saturday's game between the Pelicans and 76ers at Smoothie King Center is scheduled to start at 7:00 PM ET.

• Who: Philadelphia 76ers vs. New Orleans Pelicans
• Date: Saturday, February 21, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Smoothie King Center

Conclusion

We predict the 76ers, with a 60% win probability, will likely beat the Pelicans on Saturday, with Tyrese Maxey projected for a game-high 53 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate 76ers vs. Pelicans insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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