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Old Dominion vs. USF prediction: South Florida favored to win Cure Bowl [2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Old Dominion vs USF predictions for college football Wednesday.
South Florida will square off with Old Dominion in the 2025 Cure Bowl at Camping World Stadium on Wednesday, commencing at 5:00 PM ET.
Based on updated simulation results, Dimers' proven college football model predicts South Florida as the most likely winner of the Old Dominion vs. USF game.
This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
Cure Bowl prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the result of the 2025 Cure Bowl 10,000 times as part of our college football predictions coverage.
Our leading predictive model currently gives South Florida a 63% chance of defeating Old Dominion. Our predicted final score has South Florida winning 29-24.
According to our model, South Florida (-3.5) has a 54% chance of covering the spread, while the 52.5-point over/under has a 52% chance of staying under.
Cure Bowl odds
We have researched the best college football odds in America for this game, which are listed here:
| Bet Type | Old Dominion | USF |
|---|---|---|
| Spread | +3.5 (-105) | -3.5 (-110) |
| Moneyline | +160 | -172 |
| Total | o52.5 (-110) | u52.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Old Dominion vs. USF picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Florida -3.5 | -110 |
| Moneyline | South Florida | -172 |
| Total | Under 52.5 | -108 |
According to our college football best bets, the top play to make on this game is South Florida -3.5 at the spread.
Old Dominion vs. USF game-day updates and essential details
Wednesday's college football action between USF and Old Dominion at Camping World Stadium is scheduled to start at 5:00 PM ET.
- Who: Old Dominion vs. South Florida
- Date: Wednesday, December 17, 2025
- Time: 5:00 PM ET/2:00PM PT
- Venue: Camping World Stadium
Conclusion
We predict South Florida, with a 63% win probability, will likely beat Old Dominion on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Old Dominion vs. South Florida insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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