Old Dominion vs. USF prediction: South Florida favored to win Cure Bowl [2025]

South Florida and Old Dominion will meet in the 2025 Cure Bowl at Camping World Stadium on Wednesday, with kickoff at 5:00 PM ET.

Based on the latest simulation results, Dimers' proven college football model predicts South Florida as the most likely winner of the Old Dominion vs. USF game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Cure Bowl prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of the 2025 Cure Bowl 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives South Florida a 61% chance of defeating Old Dominion. Our predicted final score has South Florida winning 28-24.

According to our model, South Florida (-2.5) has a 59% chance of covering the spread, while the over/under total of 52.5 points has a 55% chance of staying under.

Cure Bowl odds

We have researched the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Old Dominion vs. USF picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: