Notre Dame vs. Vanderbilt prediction: Vanderbilt favored to win women's March Madness Sweet Sixteen matchup [3/27/2026]

Vanderbilt and Notre Dame are scheduled to meet in women's March Madness Sweet Sixteen action at Dickies Arena on Friday, with tipoff at 2:30 PM ET.

Based on updated simulation results, Dimers' new women's basketball model predicts Vanderbilt as the most likely winner of the Notre Dame vs. Vanderbilt game.

This article offers a closer look at Friday's matchup, including best bets and picks.

Notre Dame vs. Vanderbilt prediction: Who will win and advance to the Elite Eight?

Using powerful machine learning and data, we have simulated the result of Friday's NCAAW Tournament game between Notre Dame and Vanderbilt, forming part of our women's college basketball predictions coverage.

Our independent predictive model gives Vanderbilt a 75% chance of defeating Notre Dame.

According to our model, the over/under total of 151.5 points has a 52% chance of going over.

Notre Dame vs. Vanderbilt odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Notre Dame vs. Vanderbilt picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our women's college basketball best bets, the top play to make on this game is Vanderbilt to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Notre Dame vs. Vanderbilt game-day updates and essential details

Friday's women's basketball matchup between Vanderbilt and Notre Dame at Dickies Arena is scheduled to start at 2:30 PM ET.

• Who: Notre Dame vs. Vanderbilt
• Date: Friday, March 27, 2026
• Time: 2:30 PM ET/11:30AM PT
• Venue: Dickies Arena
• March Madness stage: Sweet 16

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Conclusion

We predict Vanderbilt, with a 75% win probability, will likely beat Notre Dame this women's March Madness Sweet Sixteen matchup.

AI and automation have enhanced this article to quickly deliver accurate Notre Dame vs. Vanderbilt insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.

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