NFL Week 2 straight up picks: Expert predictions for every game [2025]

At Dimers.com, we offer NFL picks straight up for Week 2 and beyond, as part of our in-depth NFL picks and NFL predictions coverage.

With Week 2 of the NFL season here, we've used our powerful predictive analytics model to deliver a list of NFL straight up picks for all 16 games this week.

Gain the edge in your NFL pick 'em competitions by following our data-driven NFL Week 2 picks straight up, powered by thousands of game simulations.

Week 2 of the NFL season features 16 games, starting with the Washington Commanders facing the Green Bay Packers on Thursday night and wrapping up with the Los Angeles Chargers taking on the Las Vegas Raiders on Monday night.

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NFL picks this week straight up: Week 2, 2025

Here are our Week 2 NFL picks, highlighting how likely each team is to win their game this week.

Washington Commanders vs. Green Bay Packers

The Commanders kick off Week 2 against the Packers at Lambeau Field on Thursday night. According to our predictive analytics model, the Packers have a 61% chance of winning, while the Commanders have a 39% chance.

For Week 2's opening game, our model highlights NFL player props with Austin Ekeler (RB) as the most likely player from the Commanders to score the first TD at 7.1%, while Josh Jacobs (RB) is the top candidate from the Packers at 15.7%.

The Washington Commanders vs. Green Bay Packers game at Lambeau Field is scheduled for Thursday, September 11 at 8:15pm. All times mentioned in this article are in Eastern Standard Time (EST).

Los Angeles Rams vs. Tennessee Titans

For this week's game between the Rams and the Titans, LA Rams is more likely to win. Our prediction model gives the Rams a 69% chance of winning. On the other hand, there is a 31% chance that the Titans will win.

The Los Angeles Rams vs. Tennessee Titans matchup at Nissan Stadium will take place on Sunday, September 14 at 1:00pm.

As the season heats up, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Seattle Seahawks vs. Pittsburgh Steelers

We are picking the Steelers to win their game against the Seahawks this week, with our trusted NFL model projecting a 60% win probability for the home team. The Seahawks have a 40% chance of winning at Acrisure Stadium.

For betting purposes, the Steelers are listed as -2.5 favorites, with the Seahawks' moneyline at +130.

The Seattle Seahawks vs. Pittsburgh Steelers game at Acrisure Stadium is slated for Sunday, September 14 at 1:00pm.

Buffalo Bills vs. New York Jets

According to our predictive analytics model, the Bills are the team to beat in this game, with their win probability at 72%. The Jets, on the other hand, have a 28% chance of winning.

The Buffalo Bills vs. New York Jets game at MetLife Stadium is set for Sunday, September 14 at 1:00pm.

Chicago Bears vs. Detroit Lions

The Lions have a 71% chance of winning on Sunday afternoon, compared to the Bears' 29% chance of victory. This makes the Detroit Lions our pick to win at Ford Field.

The Chicago Bears vs. Detroit Lions matchup at Ford Field is scheduled for Sunday, September 14 at 1:00pm.

New York Giants vs. Dallas Cowboys

The Cowboys are favored to win their game this week, with our predictive analytics model giving them a 67% chance, while the Giants enter the weekend with a 33% chance of causing an upset at AT&T Stadium.

When it comes to betting on this game, the Giants' moneyline odds are set at +220, with the home team Cowboys listed as -6 favorites.

The New York Giants vs. Dallas Cowboys game at AT&T Stadium will take place on Sunday, September 14 at 1:00pm.

Cleveland Browns vs. Baltimore Ravens

After 10,000 simulations of Browns vs. Ravens this Sunday, our model projects the Ravens as the more likely winners with a probability of 86%. Their opponents, the Browns, have a 14% chance of getting the win on the road.

The Cleveland Browns vs. Baltimore Ravens matchup at M&T Bank Stadium is slated for Sunday, September 14 at 1:00pm.

San Francisco 49ers vs. New Orleans Saints

DimersBOT is picking the 49ers, who have a 67% chance of winning the matchup, while the Saints have a 33% chance of an upset win.

The San Francisco 49ers vs. New Orleans Saints game at Caesars Superdome will take place on Sunday, September 14 at 1:00pm.

New England Patriots vs. Miami Dolphins

The next game of Week 2 sees the Patriots take on the Dolphins at Hard Rock Stadium.

We predict the Dolphins to win with a probability of 55%, while the Patriots are projected to have a win chance of 45%.

As for the Vegas betting odds here, the Dolphins are listed as -1.5 favorites, with the Patriots' moneyline odds posted at +105.

The New England Patriots vs. Miami Dolphins game at Hard Rock Stadium is scheduled for Sunday, September 14 at 1:00pm.

Jacksonville Jaguars vs. Cincinnati Bengals

The likely winner of this matchup is the Bengals, who have a projected win chance of 61%, according to DimersBOT. On the other side of this matchup, the Jaguars have a projected win probability of 39%.

The Jacksonville Jaguars vs. Cincinnati Bengals matchup at Paycor Stadium is set for Sunday, September 14 at 1:00pm.

Carolina Panthers vs. Arizona Cardinals

We have run our powerful NFL model over this week’s Panthers-Cardinals clash 10,000 times, with the Cardinals coming out as the team to pick. Of those 10,000 simulations, the Cardinals won 7,241 times, with the Panthers winning on 2,759 occasions.

The Carolina Panthers vs. Arizona Cardinals game at State Farm Stadium is scheduled for Sunday, September 14 at 4:05pm.

Denver Broncos vs. Indianapolis Colts

Next up is the game between the Broncos and Colts, with our model projecting the road team as the more likely victor, with the Broncos rated as having a 59% chance of getting the W. The Colts, on the other hand, are projected to have a 41% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Broncos' moneyline odds set at -125 for this road game, while the hosting Colts are listed as +1.5 underdogs.

The Denver Broncos vs. Indianapolis Colts game at Lucas Oil Stadium will take place on Sunday, September 14 at 4:05pm.

Philadelphia Eagles vs. Kansas City Chiefs

Our next straight up pick this week is for the Chiefs to get the win against the Eagles. After running 10,000 simulations of this matchup, the Kansas City have a win probability of 54%, with the Eagles at 46%.

The Philadelphia Eagles vs. Kansas City Chiefs game at GEHA Field at Arrowhead Stadium is slated for Sunday, September 14 at 4:25pm.

Atlanta Falcons vs. Minnesota Vikings

With a win probability of 67% on Sunday night, our straight up pick for this matchup is the Vikings, while their opponent, the Falcons, have a projected win chance of 33%.

The Atlanta Falcons vs. Minnesota Vikings game at U.S. Bank Stadium will take place on Sunday, September 14 at 8:20pm.

For a different angle on this week's NFL action, explore our NFL trends to find the latest player prop trends.

Tampa Bay Buccaneers vs. Houston Texans

The team to pick here is the Texans, who have a 58% chance of winning their matchup against the Buccaneers this Sunday night.

Looking at the betting odds for this Monday Night Football clash, the Texans are listed as -2.5 favorites at home, with the Buccaneers' moneyline odds available at +126.

The Tampa Bay Buccaneers vs. Houston Texans game at NRG Stadium is scheduled for Monday, September 15 at 7:00pm.

Los Angeles Chargers vs. Las Vegas Raiders

Our pick to win the final game of Week 2 is the Chargers, who have a win probability of 62%. Their opponents are projected to have a 38% chance of getting the W.

The Los Angeles Chargers vs. Las Vegas Raiders game at Allegiant Stadium is set for Monday, September 15 at 10:00pm.

Full list of NFL Week 2 picks straight up

• Packers (61% win probability)
• Rams (69%)
• Steelers (60%)
• Bills (72%)
• Lions (71%)
• Cowboys (67%)
• Ravens (86%)
• 49ers (67%)
• Dolphins (55%)
• Bengals (61%)
• Cardinals (72%)
• Broncos (59%)
• Chiefs (54%)
• Vikings (67%)
• Texans (58%)
• Chargers (62%)

NFL straight up picks and predictions for Week 2

The NFL Week 2 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.