NFL best bets today: Week 17 picks include Saints vs. Titans play [12/28/2025]

Saints -1.5 (-110)

• Edge: 5.8%
• Probability: 58.2%
• Matchup: Saints vs. Titans (1:00PM ET, Sunday)

Our model has identified value on Saints -1.5 at -110 odds. A 58.2% probability produces an edge of 5.8%, making this the strongest play for today's NFL slate.

Saints ML (-122)

• Edge: 4.3%
• Probability: 59.3%
• Matchup: Saints vs. Titans (1:00PM ET, Sunday)

Saints ML carries a 4.3% edge and a probability of 59.3% at -122 odds, according to our model.

Colts +5.5 (-104)

• Edge: 3.2%
• Probability: 54.2%
• Matchup: Jaguars vs. Colts (1:00PM ET, Sunday)

Colts +5.5 vs. Jaguars at -104 odds shows a 3.2% edge, supported by a 54.2% probability in simulations.

Panthers +7 (-105)

• Edge: 3.0%
• Probability: 54.2%
• Matchup: Seahawks vs. Panthers (1:00PM ET, Sunday)

A 3.0% edge and 54.2% probability make Panthers +7 vs. Seahawks at a value play in the Seahawks vs. Panthers matchup, per our model.

Colts ML (+220)

• Edge: 3.0%
• Probability: 34.3%
• Matchup: Jaguars vs. Colts (1:00PM ET, Sunday)

Colts ML at +220 odds presents a 3.0% edge, with simulations resulting in a probability of 34.3%.

NFL best bets summary: Sunday, 12/28/2025

As of 3:02AM ET, here are our top NFL bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Saints vs. Titans	Saints -1.5	-110 @ BetMGM	5.8%	58.2%
Saints vs. Titans	Saints ML	-122 @ DraftKings	4.3%	59.3%
Jaguars vs. Colts	Colts +5.5	-104 @ FanDuel	3.2%	54.2%
Seahawks vs. Panthers	Panthers +7	-105 @ BetMGM	3.0%	54.2%
Jaguars vs. Colts	Colts ML	+220 @ FanDuel	3.0%	34.3%

List of upcoming NFL games to bet on [12/28/2025]

• Buccaneers vs. Dolphins (1:00PM ET, Sunday)
• Patriots vs. Jets (1:00PM ET, Sunday)
• Steelers vs. Browns (1:00PM ET, Sunday)
• Saints vs. Titans (1:00PM ET, Sunday)
• Jaguars vs. Colts (1:00PM ET, Sunday)
• Cardinals vs. Bengals (1:00PM ET, Sunday)
• Seahawks vs. Panthers (1:00PM ET, Sunday)
• Giants vs. Raiders (4:05PM ET, Sunday)
• Eagles vs. Bills (4:25PM ET, Sunday)
• Bears vs. 49ers (8:20PM ET, Sunday)

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Conclusion

Our NFL best bets are locked and loaded for December 28, 2025, featuring plays such as Saints -1.5 and Saints ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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