NFL best bets today: Week 17 picks highlight Giants vs. Raiders play [12/28/2025]

Today’s NFL picks for December 28, 2025 are here, with Giants vs. Raiders among the top plays identified by our model across Sunday’s NFL action.

Dimers’ predictive analytics engine runs 24/7, searching the latest football odds to uncover genuine betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of NFL best bets today [12/28, updated 4:01PM ET]

Below, you’ll find today’s best football bets, ranked by edge for Sunday, December 28, 2025.

Giants ML (-154)

• Edge: 3.5%
• Probability: 64.1%
• Matchup: Giants vs. Raiders (4:05PM ET, Sunday)

Our model has identified value on Giants to defeat Raiders at -154 odds. A 64.1% probability produces an edge of 3.5%, making this the strongest play for today's NFL slate.

NFL best bets summary: Sunday, 12/28/2025

As of 4:01PM ET, here is our top NFL bet by edge recommended by our model:

List of upcoming NFL games to bet on [12/28/2025]

• Giants vs. Raiders (4:05PM ET, Sunday)
• Eagles vs. Bills (4:25PM ET, Sunday)
• Bears vs. 49ers (8:20PM ET, Sunday)

See How Dimers Pro Enhances Your Best Bets

Discover the difference our best bets make with Dimers Pro. Check out this explainer video to see how you can gain an edge.

AI betting support with Dimebot

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Conclusion

Our NFL best bets are locked and loaded for December 28, 2025, featuring plays such as Giants ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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