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NFL best bets today: Week 17 picks include Saints vs. Titans play [12/28/2025]
Get NFL best bets and predictions for Sunday, December 28, 2025.

Today’s NFL picks for December 28, 2025 are here, with Saints vs. Titans among the top plays identified by our model across Sunday’s NFL slate.
Dimers’ predictive analytics engine runs 24/7, going over the latest football odds to uncover real betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of NFL best bets today [12/28, updated 3:02AM ET]
Below, you’ll find today’s best football bets, ranked by edge for Sunday, December 28, 2025.
Saints -1.5 (-110)
- Edge: 5.8%
- Probability: 58.2%
- Matchup: Saints vs. Titans (1:00PM ET, Sunday)
Our model has identified value on Saints -1.5 at -110 odds. A 58.2% probability produces an edge of 5.8%, making this the strongest play for today's NFL slate.
Saints ML (-122)
- Edge: 4.3%
- Probability: 59.3%
- Matchup: Saints vs. Titans (1:00PM ET, Sunday)
Saints ML carries a 4.3% edge and a probability of 59.3% at -122 odds, according to our model.
Colts +5.5 (-104)
- Edge: 3.2%
- Probability: 54.2%
- Matchup: Jaguars vs. Colts (1:00PM ET, Sunday)
Colts +5.5 vs. Jaguars at -104 odds shows a 3.2% edge, supported by a 54.2% probability in simulations.
Panthers +7 (-105)
- Edge: 3.0%
- Probability: 54.2%
- Matchup: Seahawks vs. Panthers (1:00PM ET, Sunday)
A 3.0% edge and 54.2% probability make Panthers +7 vs. Seahawks at a value play in the Seahawks vs. Panthers matchup, per our model.
Colts ML (+220)
- Edge: 3.0%
- Probability: 34.3%
- Matchup: Jaguars vs. Colts (1:00PM ET, Sunday)
Colts ML at +220 odds presents a 3.0% edge, with simulations resulting in a probability of 34.3%.
NFL best bets summary: Sunday, 12/28/2025
As of 3:02AM ET, here are our top NFL bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Saints vs. Titans | Saints -1.5 | -110 @ BetMGM | 5.8% | 58.2% |
| Saints vs. Titans | Saints ML | -122 @ DraftKings | 4.3% | 59.3% |
| Jaguars vs. Colts | Colts +5.5 | -104 @ FanDuel | 3.2% | 54.2% |
| Seahawks vs. Panthers | Panthers +7 | -105 @ BetMGM | 3.0% | 54.2% |
| Jaguars vs. Colts | Colts ML | +220 @ FanDuel | 3.0% | 34.3% |
List of upcoming NFL games to bet on [12/28/2025]
- Buccaneers vs. Dolphins (1:00PM ET, Sunday)
- Patriots vs. Jets (1:00PM ET, Sunday)
- Steelers vs. Browns (1:00PM ET, Sunday)
- Saints vs. Titans (1:00PM ET, Sunday)
- Jaguars vs. Colts (1:00PM ET, Sunday)
- Cardinals vs. Bengals (1:00PM ET, Sunday)
- Seahawks vs. Panthers (1:00PM ET, Sunday)
- Giants vs. Raiders (4:05PM ET, Sunday)
- Eagles vs. Bills (4:25PM ET, Sunday)
- Bears vs. 49ers (8:20PM ET, Sunday)
See How Dimers Pro Enhances Your Best Bets
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What Is Dimebot?
Dimebot is Dimers’ AI bet assistant, designed to surface swift insights, answer betting questions, and help you explore data more efficiently.
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Conclusion
Our NFL best bets are locked and loaded for December 28, 2025, featuring plays such as Saints -1.5 and Saints ML. Powered by advanced simulations, these picks are here to boost your betting game.
This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
All odds and probabilities in this article are correct and accurate at the time of publication.
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