NFL best bets today: Week 16 picks include Falcons vs. Cardinals play [12/21/2025]

Today’s NFL picks for December 21, 2025 are here, with Falcons vs. Cardinals and Patriots vs. Ravens among the top plays identified by our model across Sunday’s NFL play.

Dimers’ predictive analytics engine runs 24/7, searching the latest football odds to unearth real betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of NFL best bets today [12/21, updated 4:05PM ET]

Below, you’ll find today’s best football bets, ranked by edge for Sunday, December 21, 2025.

Cardinals +2.5 (-102)

• Edge: 7.7%
• Probability: 58.2%
• Matchup: Falcons vs. Cardinals (4:05PM ET, Sunday)

Our model has identified value on Cardinals +2.5 at -102 odds. A 58.2% probability produces an edge of 7.7%, making this the strongest play for today's NFL slate.

Patriots +3 (+100)

• Edge: 6.5%
• Probability: 56.5%
• Matchup: Patriots vs. Ravens (8:20PM ET, Sunday)

Patriots +3 carries a 6.5% edge and a probability of 56.5% at +100 odds, according to our model.

Jaguars +3 (-105)

• Edge: 5.2%
• Probability: 56.5%
• Matchup: Jaguars vs. Broncos (4:05PM ET, Sunday)

Jaguars +3 vs. Broncos at -105 odds shows a 5.2% edge, supported by a 56.5% probability in simulations.

Steelers ML (+330)

• Edge: 4.3%
• Probability: 27.5%
• Matchup: Steelers vs. Lions (4:25PM ET, Sunday)

A 4.3% edge and 27.5% probability make Steelers at the moneyline at a value play in the Steelers vs. Lions matchup, per our model.

Raiders vs. Texans over 39 points (-110)

• Edge: 2.0%
• Probability: 54.4%
• Matchup: Raiders vs. Texans (4:25PM ET, Sunday)

Raiders vs. Texans over 39 points at -110 odds presents a 2.0% edge, with simulations resulting in a probability of 54.4%.

NFL best bets summary: Sunday, 12/21/2025

As of 4:05PM ET, here are our top NFL bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Falcons vs. Cardinals	Cardinals +2.5	-102 @ FanDuel	7.7%	58.2%
Patriots vs. Ravens	Patriots +3	+100 @ BetMGM	6.5%	56.5%
Jaguars vs. Broncos	Jaguars +3	-105 @ BetMGM	5.2%	56.5%
Steelers vs. Lions	Steelers ML	+330 @ DraftKings	4.3%	27.5%
Raiders vs. Texans	Over 39 Points	-110 @ BetMGM	2.0%	54.4%

List of upcoming NFL games to bet on [12/21/2025]

• Jaguars vs. Broncos (4:05PM ET, Sunday)
• Falcons vs. Cardinals (4:05PM ET, Sunday)
• Raiders vs. Texans (4:25PM ET, Sunday)
• Steelers vs. Lions (4:25PM ET, Sunday)
• Patriots vs. Ravens (8:20PM ET, Sunday)

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Conclusion

Our NFL best bets are locked and loaded for December 21, 2025, featuring plays such as Cardinals +2.5 and Patriots +3. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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