NFL best bets today: Week 10 picks include two spread plays [11/9/2025]

Today’s NFL picks for November 9, 2025 are here, with Lions vs. Commanders among the top plays identified by our model across Sunday’s NFL slate.

Dimers’ predictive analytics engine runs 24/7, scanning the latest football odds to uncover genuine betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of NFL best bets today [11/9, updated 3:54PM ET]

Below, you’ll find today’s best football bets, ranked by edge for Sunday, November 9, 2025.

Commanders +8.5 (-115)

• Edge: 10.8%
• Probability: 64.3%
• Matchup: Lions vs. Commanders (4:25PM ET, Sunday)

Our model has identified value on Commanders +8.5 at -115 odds. A 64.3% probability produces an edge of 10.8%, making this the strongest play for today's NFL slate.

Commanders ML (+350)

• Edge: 8.5%
• Probability: 30.7%
• Matchup: Lions vs. Commanders (4:25PM ET, Sunday)

Commanders ML carries an 8.5% edge and a probability of 30.7% at +350 odds, according to our model.

49ers +5.5 vs. Rams(-105)

• Edge: 2.9%
• Probability: 54.2%
• Matchup: Rams vs. 49ers (4:25PM ET, Sunday)

49ers +5.5 vs. Rams at -105 odds shows a 2.9% edge, supported by a 54.2% probability in simulations.

NFL best bets summary: Sunday, 11/9/2025

As of 3:54PM ET, here are our top NFL bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Lions vs. Commanders	Commanders +8.5	-115 @ DraftKings	10.8%	64.3%
Lions vs. Commanders	Commanders ML	+350 @ DraftKings	8.5%	30.7%
Rams vs. 49ers	49ers +5.5	-105 @ DraftKings	2.9%	54.2%

List of upcoming NFL games to bet on [11/9/2025]

• Cardinals vs. Seahawks (4:05PM ET, Sunday)
• Rams vs. 49ers (4:25PM ET, Sunday)
• Lions vs. Commanders (4:25PM ET, Sunday)
• Steelers vs. Chargers (8:20PM ET, Sunday)

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Conclusion

Our NFL best bets are locked and loaded for November 9, 2025, featuring plays such as Commanders +8.5 and Commanders ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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