NFL best bets today: Week 7 picks include Colts vs. Chargers play [10/19/2025]

Today’s NFL picks for October 19, 2025 are here, with Sunday’s NFL best bets backed by tens of thousands of predictive simulations analyzing the latest odds and matchups.

These NFL best bets include matchups like Colts vs. Chargers and Falcons vs. 49ers, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge NFL bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Sunday, October 19, 2025, including our full suite of picks and best bets for today and the week ahead.

List of NFL best bets today [10/19, updated 4:01PM ET]

After crunching the numbers and conducting thousands of simulations, our famous predictive analytics model has identified the best football bets for Sunday, October 19, 2025.

Colts +2.5 (-105)

• Probability: 58.2%
• Edge: 7.0%
• Matchup: Colts vs. Chargers (4:05PM ET, Sunday)

Our model has pinpointed a high-probability NFL betting opportunity today, which comes in the Colts vs. Chargers matchup. We recommend a spread bet on Colts +2.5 at -105 odds, with our analysis showing a 58.2% chance of hitting and a compelling edge of 7.0%.

Falcons ML (+100)

• Probability: 57.1%
• Edge: 7.1%
• Matchup: Falcons vs. 49ers (8:20PM ET, Sunday)

Our model has found another strong NFL bet for Sunday's sports action, this time in the game between the Falcons and 49ers. We suggest placing a wager on Falcons ML at +100 odds, with a 57.1% probability delivering a 7.1% edge.

Packers vs. Cardinals over 44.5 points (-110)

• Probability: 55.6%
• Edge: 3.2%
• Matchup: Packers vs. Cardinals (4:25PM ET, Sunday)

Our model has found another strong NFL bet for today's football action, this time in the Packers vs. Cardinals matchup. We recommend an over/under bet on **over 44.5 points ** at -110 odds. Our projections shows a 55.6% probability and 3.2% edge for this wager.

NFL best bets: Sunday, 10/19/2025

As of 4:01PM ET, here are our top three NFL bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Colts vs. Chargers	Colts +2.5	-105 @ BetMGM	58.2%	7.0%
Falcons vs. 49ers	Falcons ML	+100 @ BetMGM	57.1%	7.1%
Packers vs. Cardinals	Over 44.5 Points	-110 @ DraftKings	55.6%	3.2%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to three NFL picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for October 19, 2025.

List of upcoming NFL games to bet on [10/19/2025]

• Giants vs. Broncos (4:05PM ET, Sunday)
• Colts vs. Chargers (4:05PM ET, Sunday)
• Commanders vs. Cowboys (4:25PM ET, Sunday)
• Packers vs. Cardinals (4:25PM ET, Sunday)
• Falcons vs. 49ers (8:20PM ET, Sunday)

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More about NFL

The bets on this page form part of our NFL player props and NFL best bets series.

For more NFL betting content, we have NFL trends for every game, as well as daily NFL betting news and the latest Super Bowl odds and predictions.

Conclusion

Our NFL best bets are locked and loaded for October 19, 2025, featuring plays such as Colts +2.5 and Falcons ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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