NFL best bets today: Week 16 picks include Eagles vs. Commanders play [12/20/2025]

Commanders +7 (-110)

• Edge: 4.6%
• Probability: 57%
• Matchup: Eagles vs. Commanders (5:00PM ET, Saturday)

Our model has identified value on Commanders +7 at -110 odds. A 57% probability produces an edge of 4.6%, making this the strongest play for today's NFL slate.

Eagles vs. Commanders over 44.5 points (-105)

• Edge: 3.4%
• Probability: 54.6%
• Matchup: Eagles vs. Commanders (5:00PM ET, Saturday)

Eagles vs. Commanders over 44.5 points carries a 3.4% edge and a probability of 54.6% at -105 odds, according to our model.

Commanders ML (+275)

• Edge: 3.1%
• Probability: 29.8%
• Matchup: Eagles vs. Commanders (5:00PM ET, Saturday)

Commanders ML at +275 odds shows a 3.1% edge, supported by a 29.8% probability in simulations.

NFL best bets summary: Saturday, 12/20/2025

As of 2:05AM ET, here are our top NFL bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Eagles vs. Commanders	Commanders +7	-110 @ BetMGM	4.6%	57%
Eagles vs. Commanders	Over 44.5 Points	-105 @ FanDuel	3.4%	54.6%
Eagles vs. Commanders	Commanders ML	+275 @ BetMGM	3.1%	29.8%

List of upcoming NFL games to bet on [12/20/2025]

• Eagles vs. Commanders (5:00PM ET, Saturday)
• Packers vs. Bears (8:20PM ET, Saturday)

What Is Dimebot?

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Conclusion

Our NFL best bets are locked and loaded for December 20, 2025, featuring plays such as Commanders +7 and over 44.5 points also in the Eagles vs. Commanders matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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