NFL best bets today: Week 6 MNF picks include Bills vs. Falcons play [10/13/2025]

Today’s NFL picks for October 13, 2025 are here, with Monday’s NFL best bets powered by thousands of predictive simulations analyzing the latest odds and matchups.

These NFL best bets include matchups like Bills vs. Falcons and Bears vs. Commanders, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge NFL bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Monday, October 13, 2025, including our complete set of picks and best bets for today and the week ahead.

List of NFL best bets tonight [10/13, updated 7:01PM ET]

After digging deep into the numbers and running thousands of simulations, our famous predictive analytics model has identified the best football bets for Monday, October 13, 2025.

Falcons +3.5 (+100)

• Probability: 58.9%
• Edge: 8.9%
• Matchup: Bills vs. Falcons (7:15PM ET, Monday)

Our model has pinpointed a high-probability NFL betting opportunity tonight, which comes in the Bills vs. Falcons matchup. We recommend a spread bet on Falcons +3.5 at +100 odds, with our analysis showing a 58.9% chance of hitting and a compelling edge of 8.9%.

Bears vs. Commanders over 49.5 points(-104)

• Probability: 53%
• Edge: 2.0%
• Matchup: Bears vs. Commanders (8:15PM ET, Monday)

Our model has found another strong NFL bet for Monday's sports action, this time in the matchup between the Bears and Commanders. We suggest placing an over/under wager on over 49.5 points at -104 odds, with a 53% probability delivering a 2.0% edge.

Falcons ML (+172)

• Probability: 39.9%
• Edge: 3.1%
• Matchup: Bills vs. Falcons (7:15PM ET, Monday)

Our model has found another strong NFL bet for Monday's football action, this time in the Bills vs. Falcons matchup. We recommend a bet on Falcons ML at +172 odds. Our projections shows a 39.9% probability and 3.1% edge for this wager.

NFL best bets: Monday, 10/13/2025

As of 7:01PM ET, here are our top three NFL bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Bills vs. Falcons	Falcons +3.5	+100 @ DraftKings	58.9%	8.9%
Bears vs. Commanders	Over 49.5 Points	-104 @ FanDuel	53%	2.0%
Bills vs. Falcons	Falcons ML	+172 @ FanDuel	39.9%	3.1%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to three NFL picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for October 13, 2025.

List of upcoming NFL games to bet on [10/13/2025]

• Bills vs. Falcons (7:15PM ET, Monday)
• Bears vs. Commanders (8:15PM ET, Monday)

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More on NFL

The bets on this page form part of our NFL player props and NFL best bets series.

For more NFL betting content, we have NFL trends for every game, as well as daily NFL betting news and the latest Super Bowl odds and predictions.

Conclusion

Our NFL best bets are locked and loaded for October 13, 2025, featuring plays such as Falcons +3.5 and over 49.5 points in the Bears vs. Commanders matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate NFL insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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