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Read Article Yankees vs. Red Sox prediction: Yankees favored to win Wednesday's MLB matchup [4/22/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get New York Yankees vs Boston Red Sox predictions for MLB Wednesday.
The Boston Red Sox will face the New York Yankees, in what is expected to be a close MLB game, at Fenway Park on Wednesday, commencing at 6:45 PM ET.
Ranger Suarez (1-1, 3.22 ERA) will be the starting pitcher for the Red Sox, while the Yankees are going with Max Fried (2-1, 2.97 ERA).
Based on the latest simulations, Dimers' advanced MLB model gives the Yankees a slight edge with a 52% win probability over the Red Sox.
This article offers a closer look at Wednesday's Yankees vs. Red Sox matchup, including best bets and picks.
Yankees vs. Red Sox prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Yankees and Red Sox, forming part of our MLB predictions coverage.
Our famous predictive model gives the Yankees a 52% chance of defeating the Red Sox.
According to our model, the Red Sox (+1.5) have a 62% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.
Yankees vs. Red Sox odds [4/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Yankees | Red Sox |
|---|---|---|
| Run Line | -1.5 (+129) | +1.5 (-150) |
| Moneyline | -131 | +115 |
| Total | o7.5 (-105) | u7.5 (-102) |
All odds are correct at the time of publication and are subject to change.
Yankees vs. Red Sox picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Red Sox +1.5 | -150 |
| Moneyline | Red Sox | +115 |
| Total | Over 7.5 | -105 |
According to our MLB best bets, the top play to make on this game is Red Sox +1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Yankees vs. Red Sox game-day updates and essential details
Wednesday's MLB action between the Red Sox and Yankees at Fenway Park is scheduled to begin at 6:45 PM ET.
- Who: New York Yankees vs. Boston Red Sox
- Date: Wednesday, April 22, 2026
- Time: 6:45 PM ET/3:45PM PT
- Venue: Fenway Park
Conclusion
We predict the Yankees, with a 52% win probability, will likely beat the Red Sox in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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