Yankees vs. Red Sox prediction: Yankees favored to win Wednesday's MLB matchup [4/22/2026]

The Boston Red Sox will face the New York Yankees, in what is expected to be a close MLB game, at Fenway Park on Wednesday, starting at 6:45 PM ET.

Ranger Suarez (1-1, 3.22 ERA) will be the starting pitcher for the Red Sox, while the Yankees have opted for Max Fried (2-1, 2.97 ERA).

Based on the latest simulation results, Dimers' advanced MLB model gives the Yankees a slight edge with a 52% win probability over the Red Sox.

This article offers an expanded analysis of Wednesday's Yankees vs. Red Sox matchup, including best bets and picks.

Yankees vs. Red Sox prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Yankees and Red Sox, forming part of our MLB predictions coverage.

Our independent predictive model currently gives the Yankees a 52% chance of beating the Red Sox.

According to our model, the Red Sox (+1.5) have a 61% chance of covering the run line, while the 8-run over/under has a 51% chance of staying under.

Yankees vs. Red Sox odds [4/22/2026]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Yankees vs. Red Sox picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: