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Patriots vs. Saints prediction: New England favored to win in NFL Week 6, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get New England Patriots vs New Orleans Saints predictions for NFL Sunday.
The New Orleans Saints will face the New England Patriots in NFL Week 6 action at Caesars Superdome on Sunday, beginning at 1:00PM ET.
Based on the latest simulation results, Dimers' advanced NFL model projects the Patriots as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's Patriots-Saints game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Patriots with a win probability of 61%, while the Saints have 39%."
This gameday Patriots vs. Saints betting preview builds on my Patriots vs. Saints prediction that was published earlier in the week.
For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive Patriots vs. Saints predictions page.
Patriots vs. Saints predictions
Since our Patriots-Saints predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Patriots and Saints 10,000 times as part of our NFL predictions coverage.
Our famous predictive model gives the Patriots a 61% chance of defeating the Saints in Week 6 of the NFL season. Our predicted final score has the Patriots winning 24-21.
According to our model, the Saints (+3.5) have a 59% chance of covering the spread, while the over/under total of 46.5 points has an equal 50-50 chance of hitting.
To see win probabilities for every matchup this week, check out our expert NFL Week 6 straight up picks.
Patriots vs. Saints odds
We have researched the best NFL odds in America for this game, which are listed here:
| Bet Type | Patriots | Saints |
|---|---|---|
| Spread | -3.5 (+100) | +3.5 (-115) |
| Moneyline | -180 | +160 |
| Total | o46.5 (-105) | u46.5 (-115) |
All odds are correct at the time of publication and are subject to change.
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Patriots vs. Saints picks and best bets
Our model's strongest edge in today's Patriots vs. Saints matchup is on the total.
Our expert predictions, matched against the current odds, reveal the best NFL picks and NFL best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Patriots vs. Saints TD scorers
Who will score an anytime touchdown in Patriots vs. Saints?
According to our list of touchdown scorer predictions for Week 6, New England's Rhamondre Stevenson is most likely to score the first TD in Patriots vs. Saints.
Our projections give Stevenson a 9.5% chance of getting in for six first at Caesars Superdome, while the Patriots running back is a 40.0% chance of reaching the end zone at any point in the game.
First touchdown scorer predictions
New England Patriots
| Player | First TD Probability |
|---|---|
| Rhamondre Stevenson (RB) | 9.5% |
| TreVeyon Henderson (RB) | 8.7% |
| Stefon Diggs (WR) | 6.9% |
New Orleans Saints
| Player | First TD Probability |
|---|---|
| Alvin Kamara (RB) | 7.3% |
| Chris Olave (WR) | 6.0% |
| Rashid Shaheed (WR) | 5.9% |
Anytime touchdown scorer predictions
New England Patriots
| Player | Anytime TD Probability |
|---|---|
| Rhamondre Stevenson (RB) | 40.0% |
| TreVeyon Henderson (RB) | 37.2% |
| Stefon Diggs (WR) | 30.9% |
New Orleans Saints
| Player | Anytime TD Probability |
|---|---|
| Alvin Kamara (RB) | 31.3% |
| Chris Olave (WR) | 26.6% |
| Rashid Shaheed (WR) | 26.3% |
Patriots vs Saints player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Patriots and Saints. For detailed projections, join Dimers Pro.
Already a Dimers Pro member? Head to our NFL player projections page now to access player prop projections for every offensive player in this matchup and all other Week 6 games.
Patriots vs. Saints quarterbacks
Of the starting quarterbacks, the Patriots' Drake Maye is projected to throw for more yards than the Saints' Spencer Rattler.
Patriots rushing
Rhamondre Stevenson, TreVeyon Henderson and Drake Maye are projected to be the leading rushers for the Patriots.
| Player | Position |
|---|---|
| Rhamondre Stevenson | RB |
| TreVeyon Henderson | RB |
| Drake Maye | QB |
Saints rushing
Alvin Kamara, Kendre Miller and Spencer Rattler are expected to lead the Saints in rushing yards.
| Player | Position |
|---|---|
| Alvin Kamara | RB |
| Kendre Miller | RB |
| Spencer Rattler | QB |
Patriots receiving
Stefon Diggs, Hunter Henry, Kayshon Boutte, TreVeyon Henderson and Rhamondre Stevenson are projected to top the receiving yards for the Patriots.
| Player | Position |
|---|---|
| Stefon Diggs | WR |
| Hunter Henry | TE |
| Kayshon Boutte | WR |
| TreVeyon Henderson | RB |
| Rhamondre Stevenson | RB |
Saints receiving
Chris Olave, Rashid Shaheed, Juwan Johnson, Alvin Kamara and Brandin Cooks are projected to lead the Saints in receiving yards.
| Player | Position |
|---|---|
| Chris Olave | WR |
| Rashid Shaheed | WR |
| Juwan Johnson | TE |
| Alvin Kamara | RB |
| Brandin Cooks | WR |
Patriots vs. Saints game-day updates and essential details
The NFL Week 6 action between the Saints and Patriots at Caesars Superdome is scheduled to start at 1:00PM ET.
- Who: New England Patriots vs. New Orleans Saints
- Date: Sunday, October 12, 2025
- Time: 1:00PM ET/10:00AM PT
- Venue: Caesars Superdome
Dimers' comprehensive preview of Sunday's Patriots vs. Saints matchup includes our prediction, picks and the latest betting odds.
Before making any Patriots vs. Saints picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.
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Conclusion
We predict the Patriots, with a 61% win probability, will likely beat the Saints in Week 6 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Patriots vs. Saints insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on NFL
Keep up with the latest NFL news and NFL parlay picks throughout the season. Plus, our Super Bowl odds provide the most up-to-date projections for the Super Bowl, AFC, NFC and each division.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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