Omaha vs. South Dakota prediction: Nebraska-Omaha favored to win men's college basketball matchup [2/25/2026]

South Dakota and Omaha will lock horns in men's college basketball action at Sanford Coyote Sports Center on Wednesday, with tipoff at 7:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model projects Nebraska-Omaha as the most likely winner of the Omaha vs. South Dakota game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Omaha vs. South Dakota prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball matchup between Omaha and South Dakota 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Nebraska-Omaha a 57% chance of defeating South Dakota. Our predicted final score has Nebraska-Omaha winning 78-76.

According to our model, Nebraska-Omaha (+1.5) has a 61% chance of covering the spread, while the 153.5-point over/under has a 52% chance of going over.

Omaha vs. South Dakota odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Omaha vs. South Dakota picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Nebraska-Omaha +1.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Omaha vs. South Dakota game-day updates and essential details

Wednesday's men's college basketball matchup between South Dakota and Omaha at Sanford Coyote Sports Center is scheduled to start at 7:00 PM ET.

• Who: Nebraska-Omaha vs. South Dakota
• Date: Wednesday, February 25, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Sanford Coyote Sports Center

Conclusion

We predict Nebraska-Omaha, with a 57% win probability, will likely beat South Dakota on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Nebraska-Omaha vs. South Dakota insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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