MLB picks today: Wednesday's MLB best bets include Rays vs. Guardians play [4/29/2026]

Rays -1.5 (+184)

• Edge: 7.0%
• Probability: 42.3%
• Matchup: Rays vs. Guardians (1:10PM ET, Wednesday)

Our model has identified value on Rays -1.5 at +184 odds. A 42.3% probability produces an edge of 7.0%, making this the strongest play for today's MLB slate.

Rays vs. Guardians over 7 runs (+100)

• Edge: 5.2%
• Probability: 55.2%
• Matchup: Rays vs. Guardians (1:10PM ET, Wednesday)

Rays vs. Guardians over 7 runs carries a 5.2% edge and a probability of 55.2% at +100 odds, according to our model.

Rockies vs. Reds over 9.5 runs (+100)

• Edge: 3.3%
• Probability: 53.3%
• Matchup: Rockies vs. Reds (6:40PM ET, Wednesday)

Rockies vs. Reds over 9.5 runs at +100 odds shows a 3.3% edge, supported by a 53.3% probability in simulations.

Mariners vs. Twins over 8 runs (+100)

• Edge: 3.2%
• Probability: 53.2%
• Matchup: Mariners vs. Twins (1:40PM ET, Wednesday)

A 3.2% edge and 53.2% probability make Mariners vs. Twins over 8 runs at a value play in the Mariners vs. Twins matchup, per our model.

Red Sox vs. Blue Jays over 8.5 runs (+100)

• Edge: 2.9%
• Probability: 52.9%
• Matchup: Red Sox vs. Blue Jays (3:07PM ET, Wednesday)

Red Sox vs. Blue Jays over 8.5 runs at +100 odds presents a 2.9% edge, with simulations resulting in a probability of 52.9%.

Giants vs. Phillies over 7 runs (-110)

• Edge: 2.6%
• Probability: 54.9%
• Matchup: Giants vs. Phillies (6:40PM ET, Wednesday)

Our model finds value on over 7 runs in Giants vs. Phillies at -110 odds, supported by an edge of 2.6%.

Diamondbacks vs. Brewers over 8.5 runs (-110)

• Edge: 2.3%
• Probability: 54.7%
• Matchup: Diamondbacks vs. Brewers (7:40PM ET, Wednesday)

Our model has uncovered value on Diamondbacks vs. Brewers over 8.5 runs at -110 odds. A 54.7% probability produces a 2.3% edge, making this a strong play for today's MLB action.

Astros vs. Orioles over 9 runs (-102)

• Edge: 2.1%
• Probability: 52.6%
• Matchup: Astros vs. Orioles (6:35PM ET, Wednesday)

A 2.1% edge on a 52.6% probability makes over 9 runs at -102 odds a solid value play in today's Astros vs. Orioles matchup.

MLB best bets summary: Wednesday, 4/29/2026

As of 7:04AM ET, here are our top MLB bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Rays vs. Guardians	Rays -1.5	+184 @ FanDuel	7.0%	42.3%
Rays vs. Guardians	Over 7 Runs	+100 @ DraftKings	5.2%	55.2%
Rockies vs. Reds	Over 9.5 Runs	+100 @ BetMGM	3.3%	53.3%
Mariners vs. Twins	Over 8 Runs	+100 @ FanDuel	3.2%	53.2%
Red Sox vs. Blue Jays	Over 8.5 Runs	+100 @ BetMGM	2.9%	52.9%
Giants vs. Phillies	Over 7 Runs	-110 @ BetMGM	2.6%	54.9%
Diamondbacks vs. Brewers	Over 8.5 Runs	-110 @ FanDuel	2.3%	54.7%
Astros vs. Orioles	Over 9 Runs	-102 @ DraftKings	2.1%	52.6%

List of upcoming MLB games to bet on [4/29/2026]

• Rays vs. Guardians (1:10PM ET, Wednesday)
• Angels vs. White Sox (1:10PM ET, Wednesday)
• Mariners vs. Twins (1:40PM ET, Wednesday)
• Yankees vs. Rangers (2:35PM ET, Wednesday)
• Red Sox vs. Blue Jays (3:07PM ET, Wednesday)
• Marlins vs. Dodgers (3:10PM ET, Wednesday)
• Cubs vs. Padres (4:10PM ET, Wednesday)
• Astros vs. Orioles (6:35PM ET, Wednesday)
• Cardinals vs. Pirates (6:40PM ET, Wednesday)
• Giants vs. Phillies (6:40PM ET, Wednesday)
• Rockies vs. Reds (6:40PM ET, Wednesday)
• Nationals vs. Mets (7:10PM ET, Wednesday)
• Tigers vs. Braves (7:15PM ET, Wednesday)
• D-Backs vs. Brewers (7:40PM ET, Wednesday)
• Royals vs. Athletics (9:40PM ET, Wednesday)

Conclusion

Our MLB best bets are locked and loaded for April 29, 2026, featuring plays such as Rays -1.5 and over 7 runs also in the Rays vs. Guardians matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.