MLB picks today: Monday's MLB best bets include Diamondbacks vs. Mets play [4/6/2026]

Today’s MLB picks for April 06, 2026 are here, with Diamondbacks vs. Mets and Orioles vs. White Sox among the top plays identified by our model across Monday’s MLB action.

Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to discover genuine betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of MLB best bets tonight [4/6, updated 9:37PM ET]

Below, you’ll find today’s top 10 baseball bets, ranked by edge for Monday, April 6, 2026.

Diamondbacks vs. Mets over 7 runs (+100)

• Edge: 7.7%
• Probability: 57.7%
• Matchup: Diamondbacks vs. Mets (4:10PM ET, Tuesday)

Our model has identified value on over 7 runs in Diamondbacks vs. Mets at +100 odds. A 57.7% probability produces an edge of 7.7%, making this the strongest play for today's MLB slate.

Orioles vs. White Sox over 7 runs (-105)

• Edge: 7.0%
• Probability: 58.3%
• Matchup: Orioles vs. White Sox (3:10PM ET, Tuesday)

Orioles vs. White Sox over 7 runs carries a 7.0% edge and a probability of 58.3% at -105 odds, according to our model.

Royals vs. Guardians over 7 runs (+100)

• Edge: 6.7%
• Probability: 56.7%
• Matchup: Royals vs. Guardians (1:10PM ET, Tuesday)

Royals vs. Guardians over 7 runs at +100 odds shows a 6.7% edge, supported by a 56.7% probability in simulations.

Astros vs. Rockies over 10.5 runs (-108)

• Edge: 5.5%
• Probability: 57.5%
• Matchup: Astros vs. Rockies (8:40PM ET, Tuesday)

A 5.5% edge and 57.5% probability make Astros vs. Rockies over 10.5 runs at a value play in the Astros vs. Rockies matchup, per our model.

Brewers vs. Red Sox over 7 runs (-104)

• Edge: 5.0%
• Probability: 56%
• Matchup: Brewers vs. Red Sox (6:45PM ET, Tuesday)

Brewers vs. Red Sox over 7 runs at -104 odds presents a 5.0% edge, with simulations resulting in a probability of 56%.

Athletics vs. Yankees over 8.5 runs (-102)

• Edge: 4.7%
• Probability: 55.2%
• Matchup: Athletics vs. Yankees (7:05PM ET, Tuesday)

Our model finds value on over 8.5 runs in Athletics vs. Yankees at -102 odds, supported by an edge of 4.7%.

Tigers vs. Twins over 6.5 runs (-122)

• Edge: 4.1%
• Probability: 59.1%
• Matchup: Tigers vs. Twins (7:40PM ET, Tuesday)

Our model has uncovered value on Tigers vs. Twins over 6.5 runs at -122 odds. A 59.1% probability produces a 4.1% edge, making this a strong play for today's MLB action.

Dodgers vs. Blue Jays over 7.5 runs (-115)

• Edge: 4.1%
• Probability: 57.6%
• Matchup: Dodgers vs. Blue Jays (7:07PM ET, Tuesday)

A 4.1% edge on a 57.6% probability makes over 7.5 runs at -115 odds a solid value play in today's Dodgers vs. Blue Jays matchup.

Padres vs. Pirates over 6.5 runs (-110)

• Edge: 2.8%
• Probability: 55.2%
• Matchup: Padres vs. Pirates (6:40PM ET, Tuesday)

Our model projects value on over 6.5 runs at -110 odds. A 55.2% probability produces a 2.8% edge, making the over the favorable side in Saturday’s matchup.

Cardinals vs. Nationals over 7.5 runs (-110)

• Edge: 2.7%
• Probability: 55.1%
• Matchup: Cardinals vs. Nationals (6:45PM ET, Tuesday)

Rounding out our top 10 bets, Cardinals vs. Nationals over 7.5 runs at -110 odds shows a 55.1% probability and a 2.7% edge.

MLB best bets summary: Monday, 4/6/2026

As of 9:37PM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [4/6/2026]

• Braves vs. Angels (9:38PM ET, Monday)
• Phillies vs. Giants (9:45PM ET, Monday)
• Royals vs. Guardians (1:10PM ET, Tuesday)
• Orioles vs. White Sox (3:10PM ET, Tuesday)
• D-Backs vs. Mets (4:10PM ET, Tuesday)
• Cubs vs. Rays (6:40PM ET, Tuesday)
• Reds vs. Marlins (6:40PM ET, Tuesday)
• Padres vs. Pirates (6:40PM ET, Tuesday)
• Cardinals vs. Nationals (6:45PM ET, Tuesday)
• Brewers vs. Red Sox (6:45PM ET, Tuesday)
• Athletics vs. Yankees (7:05PM ET, Tuesday)
• Dodgers vs. Blue Jays (7:07PM ET, Tuesday)
• Tigers vs. Twins (7:40PM ET, Tuesday)
• Mariners vs. Rangers (8:05PM ET, Tuesday)
• Astros vs. Rockies (8:40PM ET, Tuesday)

Using Dimebot for betting research

Learn how Dimebot helps you quickly access projections, trends, and explanations—without digging through multiple tools or pages.

Conclusion

Our MLB best bets are locked and loaded for April 6, 2026, featuring plays such as over 7 runs in the Diamondbacks vs. Mets matchup and over 7 runs in the Orioles vs. White Sox matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.

Note: Clicking links to our sportsbook partners may earn us a referral fee. Learn about how we review products and services.