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Read Article MLB picks today: Friday's MLB best bets include Orioles vs. Guardians play [4/17/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get MLB picks today and best bets for Friday, April 17, 2026.
Today’s MLB picks for April 17, 2026 are here, with Orioles vs. Guardians and Reds vs. Twins among the top plays identified by our model across Friday’s MLB play.
Dimers’ predictive analytics engine runs 24/7, searching the latest baseball odds to unearth legitimate betting edges. The result? Data-backed plays that help Dimers Pro members make smarter decisions.
List of MLB best bets tonight [4/17, updated 9:32PM ET]
Below, you’ll find today’s best baseball bets, ranked by edge for Friday, April 17, 2026.
Orioles vs. Guardians over 7.5 runs (-105)
- Edge: 6.0%
- Probability: 57.3%
- Matchup: Orioles vs. Guardians (6:10PM ET, Saturday)
Our model has identified value on over 7.5 runs in Orioles vs. Guardians at -105 odds. A 57.3% probability produces an edge of 6.0%, making this the strongest play for today's MLB slate.
Reds vs. Twins over 8 runs (-105)
- Edge: 5.3%
- Probability: 56.5%
- Matchup: Reds vs. Twins (2:10PM ET, Saturday)
Reds vs. Twins over 8 runs carries a 5.3% edge and a probability of 56.5% at -105 odds, according to our model.
Blue Jays vs. Diamondbacks over 8.5 runs (+100)
- Edge: 4.6%
- Probability: 54.6%
- Matchup: Blue Jays vs. Diamondbacks (9:40PM ET, Friday)
Blue Jays vs. Diamondbacks over 8.5 runs at +100 odds shows a 4.6% edge, supported by a 54.6% probability in simulations.
Padres vs. Angels over 8 runs (-105)
- Edge: 4.1%
- Probability: 55.3%
- Matchup: Padres vs. Angels (9:38PM ET, Friday)
A 4.1% edge and 55.3% probability make Padres vs. Angels over 8 runs at a value play in the Padres vs. Angels matchup, per our model.
Dodgers vs. Rockies over 11 runs (-120)
- Edge: 3.6%
- Probability: 58.2%
- Matchup: Dodgers vs. Rockies (8:10PM ET, Saturday)
Dodgers vs. Rockies over 11 runs at -120 odds presents a 3.6% edge, with simulations resulting in a probability of 58.2%.
Tigers vs. Red Sox over 7.5 runs (+100)
- Edge: 3.4%
- Probability: 53.4%
- Matchup: Tigers vs. Red Sox (4:10PM ET, Saturday)
Our model finds value on over 7.5 runs in Tigers vs. Red Sox at +100 odds, supported by an edge of 3.4%.
Royals vs. Yankees over 8 runs (-115)
- Edge: 3.0%
- Probability: 56.5%
- Matchup: Royals vs. Yankees (1:35PM ET, Saturday)
Our model has uncovered value on Royals vs. Yankees over 8 runs at -115 odds. A 56.5% probability produces a 3.0% edge, making this a strong play for today's MLB action.
Mets vs. Cubs over 8.5 runs (+102)
- Edge: 2.1%
- Probability: 51.6%
- Matchup: Mets vs. Cubs (2:20PM ET, Saturday)
A 2.1% edge on a 51.6% probability makes over 8.5 runs at +102 odds a solid value play in today's Mets vs. Cubs matchup.
MLB best bets summary: Friday, 4/17/2026
As of 9:32PM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Orioles vs. Guardians | Over 7.5 Runs | -105 @ BetMGM | 6.0% | 57.3% |
| Reds vs. Twins | Over 8 Runs | -105 @ BetMGM | 5.3% | 56.5% |
| Blue Jays vs. Diamondbacks | Over 8.5 Runs | +100 @ DraftKings | 4.6% | 54.6% |
| Padres vs. Angels | Over 8 Runs | -105 @ DraftKings | 4.1% | 55.3% |
| Dodgers vs. Rockies | Over 11 Runs | -120 @ FanDuel | 3.6% | 58.2% |
| Tigers vs. Red Sox | Over 7.5 Runs | +100 @ BetMGM | 3.4% | 53.4% |
| Royals vs. Yankees | Over 8 Runs | -115 @ BetMGM | 3.0% | 56.5% |
| Mets vs. Cubs | Over 8.5 Runs | +102 @ FanDuel | 2.1% | 51.6% |
List of upcoming MLB games to bet on [4/17/2026]
- Padres vs. Angels (9:38PM ET, Friday)
- Blue Jays vs. D-Backs (9:40PM ET, Friday)
- White Sox vs. Athletics (9:40PM ET, Friday)
- Rangers vs. Mariners (9:40PM ET, Friday)
- Royals vs. Yankees (1:35PM ET, Saturday)
- Reds vs. Twins (2:10PM ET, Saturday)
- Mets vs. Cubs (2:20PM ET, Saturday)
- White Sox vs. Athletics (4:05PM ET, Saturday)
- Rays vs. Pirates (4:05PM ET, Saturday)
- Giants vs. Nationals (4:05PM ET, Saturday)
- Tigers vs. Red Sox (4:10PM ET, Saturday)
- Brewers vs. Marlins (4:10PM ET, Saturday)
- Orioles vs. Guardians (6:10PM ET, Saturday)
- Cardinals vs. Astros (7:10PM ET, Saturday)
- Rangers vs. Mariners (7:15PM ET, Saturday)
- Braves vs. Phillies (7:15PM ET, Saturday)
- Dodgers vs. Rockies (8:10PM ET, Saturday)
- Blue Jays vs. D-Backs (8:10PM ET, Saturday)
Conclusion
Our MLB best bets are locked and loaded for April 17, 2026, featuring plays such as over 7.5 runs in the Orioles vs. Guardians matchup and over 8 runs in the Reds vs. Twins matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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