Brewers vs. Padres prediction: San Diego favored to win Wednesday's MLB matchup [9/24/2025]

The San Diego Padres will face the Milwaukee Brewers in MLB action at PETCO Park on Wednesday, starting at 4:10PM ET.

Dylan Cease (8-12, 4.64 ERA) will start on the mound for the Padres, pitting him against Chad Patrick (3-8, 3.66 ERA) for the Brewers.

Based on the latest simulation results, Dimers' proven MLB model projects the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Brewers-Padres game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 61%, with the Brewers at 39%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Brewers vs. Padres predictions page.

Padres vs. Brewers prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Brewers and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Padres a 61% chance of beating the Brewers.

According to our model, the Brewers (+1.5) have a 58% chance of covering the run line, while the over/under total of 7.5 runs has a 56% chance of going over.

Brewers vs. Padres odds [9/24/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Brewers	Padres
Run Line	+1.5 (-184)	-1.5 (+155)
Moneyline	+122	-144
Total	o7.5 (-105)	u7.5 (-114)

All odds are correct at the time of publication and are subject to change.

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Brewers vs. Padres picks and best bets

Our model's strongest edge in today's Brewers vs. Padres matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Brewers vs. Padres game-day updates and essential details

Wednesday's MLB action between the Padres and Brewers at PETCO Park is scheduled to start at 4:10PM ET.

• Who: Milwaukee Brewers vs. San Diego Padres
• Date: Wednesday, September 24, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers' full preview of Wednesday's Brewers vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Brewers vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 61% win probability, will likely beat the Brewers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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