March Madness picks today: Friday's First Round men's best bets highlight Louisville vs. Michigan State play [3/20/2026]

Today’s men's March Madness picks for March 20, 2026 are here, with Louisville vs. Michigan State among the First Round matchups identified as top value plays across Friday’s NCAA Tournament slate.

Dimers’ predictive analytics engine runs 24/7, going over the latest men's college basketball odds to find legitimate betting edges throughout the bracket. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of men's March Madness picks today [3/20, updated 10:14PM ET]

Below, you’ll find today’s top men's March Madness bets, ranked by edge for Friday, March 20, 2026.

Michigan State ML (-192)

• Edge: 5.9%
• Probability: 71.6%
• Matchup: Louisville vs. Michigan State (2:45PM ET, Saturday)

Our model has identified value on Michigan State to defeat Louisville at -192 odds. A 71.6% probability produces an edge of 5.9%, making this the strongest play for today's First Round slate.

List of upcoming Men's March Madness games to bet on now

• High Point vs. Arkansas (1:00PM ET, Saturday)
• Vanderbilt vs. Nebraska (1:00PM ET, Saturday)
• Louisville vs. Michigan State (2:45PM ET, Saturday)
• TCU vs. Duke (5:15PM ET, Saturday)

College basketball betting and predictions promos for Friday

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Conclusion

Today's men's March Madness best bets are locked and loaded for March 20, 2026, featuring plays such as Michigan State ML. Powered by advanced simulations, these picks are here to boost your betting game.

All odds and probabilities in this article are correct and accurate at the time of publication.