Men's college basketball picks today: Wednesday's best bets include Seattle vs. Pepperdine play [2/25/2026]

Seattle -6.5 (-110)

• Edge: 4.9%
• Probability: 57.3%
• Matchup: Seattle vs. Pepperdine (9:00PM ET, Wednesday)

Our model has identified value on Seattle -6.5 at -110 odds. A 57.3% probability produces an edge of 4.9%, making this the strongest play for today's men's college basketball slate.

Hampton +4.5 (-105)

• Edge: 4.3%
• Probability: 55.5%
• Matchup: Charleston vs. Hampton (11:00AM ET, Thursday)

Hampton +4.5 carries a 4.3% edge and a probability of 55.5% at -105 odds, according to our model.

California +3.5 (-105)

• Edge: 4.3%
• Probability: 55.5%
• Matchup: SMU vs. California (10:00PM ET, Wednesday)

California +3.5 vs. SMU at -105 odds shows a 4.3% edge, supported by a 55.5% probability in simulations.

LSU +1.5 (-102)

• Edge: 4.3%
• Probability: 54.8%
• Matchup: LSU vs. Ole Miss (9:00PM ET, Wednesday)

A 4.3% edge and 54.8% probability make LSU +1.5 vs. Ole Miss at a value play in the LSU vs. Ole Miss matchup, per our model.

Seattle ML (-290)

• Edge: 4.1%
• Probability: 78.5%
• Matchup: Seattle vs. Pepperdine (9:00PM ET, Wednesday)

Seattle ML at -290 odds presents a 4.1% edge, with simulations resulting in a probability of 78.5%.

DePaul vs. Creighton over 143.5 points (-105)

• Edge: 3.9%
• Probability: 55.1%
• Matchup: DePaul vs. Creighton (9:00PM ET, Wednesday)

Our model finds value on over 143.5 points in DePaul vs. Creighton at -105 odds, supported by an edge of 3.9%.

Colorado -6.5 (-105)

• Edge: 3.8%
• Probability: 55%
• Matchup: Kansas State vs. Colorado (9:00PM ET, Wednesday)

Our model has uncovered value on Colorado -6.5 at -105 odds. A 55% probability produces a 3.8% edge, making this a strong play for today's men's college basketball action.

Ohio State vs. Iowa over 141.5 points (-106)

• Edge: 3.8%
• Probability: 55.3%
• Matchup: Ohio State vs. Iowa (9:00PM ET, Wednesday)

A 3.8% edge on a 55.3% probability makes over 141.5 points at -106 odds a solid value play in today's Ohio State vs. Iowa matchup.

Drake +2.5 (-108)

• Edge: 3.7%
• Probability: 55.6%
• Matchup: Drake vs. Valparaiso (8:00PM ET, Wednesday)

Our model projects value on Drake +2.5 at -108 odds. A 55.6% probability produces a 3.7% edge, making Drake the favorable side in Saturday’s matchup.

Milwaukee ML (+105)

• Edge: 3.6%
• Probability: 52.4%
• Matchup: Kansas State vs. Colorado (8:00PM ET, Wednesday)

Rounding out our top 10 bets, Milwaukee to defeat Youngstown State at +105 odds shows a 52.4% probability and a 3.6% edge.

NCAAM best bets summary: Wednesday, 2/25/2026

As of 7:39PM ET, here are our top men's college basketball bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Seattle vs. Pepperdine	Seattle -6.5	-110 @ FanDuel	4.9%	57.3%
Charleston vs. Hampton	Hampton +4.5	-105 @ DraftKings	4.3%	55.5%
SMU vs. California	California +3.5	-105 @ FanDuel	4.3%	55.5%
LSU vs. Ole Miss	LSU +1.5	-102 @ FanDuel	4.3%	54.8%
Seattle vs. Pepperdine	Seattle ML	-290 @ DraftKings	4.1%	78.5%
DePaul vs. Creighton	Over 143.5 Points	-105 @ BetMGM	3.9%	55.1%
Kansas State vs. Colorado	Colorado -6.5	-105 @ BetMGM	3.8%	55%
Ohio State vs. Iowa	Over 141.5 Points	-106 @ FanDuel	3.8%	55.3%
Drake vs. Valparaiso	Drake +2.5	-108 @ DraftKings	3.7%	55.6%
Youngstown State vs. Milwaukee	Milwaukee ML	+105 @ BetMGM	3.6%	52.4%

List of upcoming men's college basketball games to bet on now

• Pittsburgh vs. Stanford (8:00PM ET, Wednesday)
• Indiana State vs. Southern Illinois (8:00PM ET, Wednesday)
• Drake vs. Valparaiso (8:00PM ET, Wednesday)
• South Florida vs. Rice (8:00PM ET, Wednesday)
• Georgia Southern vs. James Madison (8:00PM ET, Wednesday)
• Youngstown State vs. Milwaukee (8:00PM ET, Wednesday)
• East Carolina vs. UTSA (8:00PM ET, Wednesday)
• Louisiana-Monroe vs. South Alabama (8:30PM ET, Wednesday)
• Central Arkansas vs. Austin Peay (8:30PM ET, Wednesday)
• Bellarmine vs. North Alabama (8:45PM ET, Wednesday)

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Conclusion

Our men's college basketball best bets are locked and loaded for February 25, 2026, featuring plays such as Seattle -6.5 and Hampton +4.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college basketball insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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