LSU vs. Ole Miss prediction: Ole Miss favored to win men's college basketball matchup [2/25/2026]

Ole Miss will take on LSU in men's college basketball action at The Sandy and John Black Pavilion at Ole Miss on Wednesday, starting at 9:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model projects Ole Miss as the most likely winner of the LSU vs. Ole Miss game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

LSU vs. Ole Miss prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball game between LSU and Ole Miss 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Ole Miss a 57% chance of beating LSU. Our predicted final score has Ole Miss winning 75-73.

According to our model, LSU (+1.5) has a 56% chance of covering the spread, while the 148.5-point over/under has a 51% chance of going over.

LSU vs. Ole Miss odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

LSU vs. Ole Miss picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is LSU +1.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

LSU vs. Ole Miss game-day updates and essential details

Wednesday's men's college basketball action between Ole Miss and LSU at The Sandy and John Black Pavilion at Ole Miss is scheduled to commence at 9:00 PM ET.

• Who: LSU vs. Ole Miss
• Date: Wednesday, February 25, 2026
• Time: 9:00 PM ET/6:00PM PT
• Venue: The Sandy and John Black Pavilion at Ole Miss

Conclusion

We predict Ole Miss, with a 57% win probability, will likely beat LSU on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate LSU vs. Ole Miss insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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