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Loyola (MD) vs. Holy Cross prediction: Holy Cross favored to win men's college basketball matchup [2/28/2026]

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Written by Dave Garofolo

Get Loyola (MD) vs Holy Cross predictions for college basketball Saturday.

Loyola (MD)-Holy Cross Predictions and Game Preview.
Loyola (MD) vs. Holy Cross men's college basketball prediction for Saturday, February 28, 2026.

Holy Cross will face Loyola (MD) in men's college basketball action at Hart Center on Saturday, commencing at 12:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model projects Holy Cross as the most likely winner of the Loyola (MD) vs. Holy Cross game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Loyola (MD) vs. Holy Cross prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAA basketball game between Loyola (MD) and Holy Cross 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Holy Cross a 57% chance of beating Loyola (MD). Our predicted final score has Holy Cross winning 76-74.

According to our model, Holy Cross (-1.5) has a 51% chance of covering the spread, while the over/under total of 151.5 points has a 52% chance of staying under.

 

Loyola (MD) vs. Holy Cross odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type Loyola (MD) Holy Cross
Spread +1.5 (-110) -1.5 (-105)
Moneyline +105 -122
Total o151.5 (-105) u151.5 (-115)

All odds are correct at the time of publication and are subject to change.

Loyola (MD) vs. Holy Cross picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Holy Cross -1.5 -105
Moneyline Holy Cross -122
Total Under 151.5 -115

According to our men's college basketball best bets, the top play to make on this game is Holy Cross to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

 

Loyola (MD) vs. Holy Cross game-day updates and essential details

Saturday's men's college basketball action between Holy Cross and Loyola (MD) at Hart Center is scheduled to begin at 12:00 PM ET.

  • Who: Loyola (MD) vs. Holy Cross
  • Date: Saturday, February 28, 2026
  • Time: 12:00 PM ET/9:00AM PT
  • Venue: Hart Center

Conclusion

We predict Holy Cross, with a 57% win probability, will likely beat Loyola (MD) on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Loyola (MD) vs. Holy Cross insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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