Loyola Chicago vs. Saint Louis prediction: Saint Louis favored to win men's college basketball matchup [3/4/2026]

Saint Louis will face Loyola Chicago in men's college basketball action at Chaifetz Arena on Wednesday, beginning at 8:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Saint Louis as the most likely winner of the Loyola Chicago vs. Saint Louis game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Loyola Chicago vs. Saint Louis prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball matchup between Loyola Chicago and Saint Louis 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Saint Louis a 97% chance of defeating Loyola Chicago. Our predicted final score has Saint Louis winning 90-66.

According to our model, Saint Louis (-21.5) has a 53% chance of covering the spread, while the 155.5-point over/under has a 52% chance of going over.

Loyola Chicago vs. Saint Louis odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

Bet Type	Loyola Chicago	Saint Louis
Spread	+21.5 (-110)	-21.5 (-105)
Moneyline	+2500	-6502
Total	o155.5 (-105)	u155.5 (-115)

All odds are correct at the time of publication and are subject to change.

Loyola Chicago vs. Saint Louis picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Saint Louis -21.5	-105
Moneyline	Loyola Chicago	+2500
Total	Over 155.5	-105

According to our men's college basketball best bets, the top play to make on this game is Saint Louis -21.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Loyola Chicago vs. Saint Louis game-day updates and essential details

Wednesday's men's college basketball game between Saint Louis and Loyola Chicago at Chaifetz Arena is scheduled to begin at 8:00 PM ET.

• Who: Loyola Chicago vs. Saint Louis
• Date: Wednesday, March 4, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Chaifetz Arena

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Conclusion

We predict Saint Louis, with a 97% win probability, will likely beat Loyola Chicago on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Loyola Chicago vs. Saint Louis insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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