Louisville vs. Notre Dame prediction: Notre Dame favored to win women's college basketball matchup [1/15/2026]

Notre Dame and Louisville are scheduled to meet in the women's college basketball at Purcell Pavilion on Thursday, with tipoff at 6:00 PM ET.

Based on the latest simulations, Dimers' new women's basketball model projects Notre Dame as the most likely winner of the Louisville vs. Notre Dame game.

This article offers further insights into Thursday's matchup, including best bets and picks.

Louisville vs. Notre Dame prediction: Who will win?

Using trusted machine learning and data, we have simulated the result of Thursday's women's basketball matchup between Louisville and Notre Dame 10,000 times as part of our women's college basketball predictions coverage.

Our famous predictive model gives Notre Dame an 80% chance of defeating Louisville.

According to our model, the over/under total of 148.5 points has a 57% chance of staying under.

Louisville vs. Notre Dame odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Louisville vs. Notre Dame picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: