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Louisville vs. Michigan prediction: Why Michigan is favored to win women's March Madness Sweet Sixteen matchup [3/28/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Louisville vs Michigan predictions for college basketball Saturday.
Michigan and Louisville are scheduled to meet in women's March Madness Sweet Sixteen action at Dickies Arena on Saturday, with tipoff at 12:30 PM ET.
Based on updated simulation results, Dimers' new women's basketball model projects Michigan as the most likely winner of the Louisville vs. Michigan game.
This article offers an expanded analysis of Saturday's matchup, including best bets and picks.
Louisville vs. Michigan prediction: Who will win and advance to the Elite Eight?
Using powerful machine learning and data analysis, we have simulated the result of Saturday's NCAAW Tournament matchup between Louisville and Michigan, forming part of our women's college basketball predictions coverage.
Our independent predictive model currently gives Michigan a 66% chance of defeating Louisville.
According to our model, the 141.5-point over/under also has an equal 50-50 chance of hitting.
Louisville vs. Michigan odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Louisville | Michigan |
|---|---|---|
| Spread | +5.5 (-112) | -5.5 (-102) |
| Moneyline | +198 | -218 |
| Total | o141.5 (-114) | u141.5 (-106) |
All odds are correct at the time of publication and are subject to change.
Louisville vs. Michigan picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Michigan -5.5 | -102 |
| Moneyline | Louisville | +198 |
| Total | Under 141.5 | -106 |
According to our women's college basketball best bets, the top play to make on this game is Louisville to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Louisville vs. Michigan game-day updates and essential details
Saturday's women's basketball game between Michigan and Louisville at Dickies Arena is scheduled to commence at 12:30 PM ET.
- Who: Louisville vs. Michigan
- Date: Saturday, March 28, 2026
- Time: 12:30 PM ET/9:30AM PT
- Venue: Dickies Arena
- March Madness stage: Sweet 16
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Conclusion
We predict Michigan, with a 66% win probability, will likely beat Louisville this women's March Madness Sweet Sixteen matchup.
AI and automation have enhanced this article to quickly deliver accurate Louisville vs. Michigan insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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