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Rams vs. Cardinals prediction: Why Rams are favored to win in NFL Week 14, 2025

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Written by Jason Bevilacqua

Get Los Angeles Rams vs Arizona Cardinals predictions for NFL Sunday.

Los Angeles Rams-Arizona Cardinals Predictions and Game Preview.
Los Angeles Rams vs. Arizona Cardinals NFL prediction for Sunday, December 7, 2025.

The Arizona Cardinals will take on the favored Los Angeles Rams in NFL Week 14 action at State Farm Stadium on Sunday, beginning at 4:25PM ET.

Based on updated simulations, Dimers' advanced NFL model predicts the Rams as the most likely winner of the Rams vs. Cardinals game.

This article offers a closer look at Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.

Rams vs. Cardinals prediction: Who will win and cover?

Since our Rams-Cardinals predictions earlier in the week, we have simulated the result of Sunday's NFL game between the Rams and Cardinals 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the Rams a 78% chance of beating the Cardinals in Week 14 of the NFL season. Our predicted final score has the Rams winning 28-20.

According to our model, the Cardinals (+9.5) have a 53% chance of covering the spread, while the over/under total of 49.5 points has a 52% chance of staying under.

 

To see win probabilities for every matchup this week, check out our expert NFL Week 14 straight up picks.

Rams vs. Cardinals odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type Rams Cardinals
Spread -9.5 (-105) +9.5 (-110)
Moneyline -500 +400
Total o49.5 (-110) u49.5 (-110)

All odds are correct at the time of publication and are subject to change.

Rams vs. Cardinals picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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