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Clippers vs. Grizzlies prediction: Why Clippers are favored to win Friday's NBA matchup [12/5/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Los Angeles Clippers vs Memphis Grizzlies predictions for NBA Friday.
The Memphis Grizzlies and Los Angeles Clippers will meet in NBA action at FedExForum on Friday, starting at 8:00PM ET.
Based on the latest simulations and today’s injury news, Dimers' advanced NBA model predicts the Clippers as the most likely winner of the Clippers vs. Grizzlies game.
This prediction follows the latest NBA Injury Report, which suggests the Grizzlies lineup will feature players like Jaren Jackson, Zach Edey and Cedric Coward, while the Clippers will be led by James Harden, Kawhi Leonard and Ivica Zubac.
This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Clippers vs. Grizzlies prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the outcome of Friday's NBA matchup between the Clippers and Grizzlies 10,000 times as part of our NBA predictions coverage.
Our independent predictive model currently gives the Clippers a 57% chance of beating the Grizzlies. Our predicted final score has the Clippers winning 112-111.
According to our model, the Clippers (-2.5) have a 53% chance of covering the spread, while the over/under total of 222.5 points has a 52% chance of going over.
Clippers vs. Grizzlies odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | Clippers | Grizzlies |
|---|---|---|
| Spread | -2.5 (-105) | +2.5 (-115) |
| Moneyline | -126 | +114 |
| Total | o222.5 (-110) | u222.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Clippers vs. Grizzlies picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Clippers -2.5 | -105 |
| Moneyline | Clippers | -126 |
| Total | Over 222.5 | -110 |
According to our best NBA bets for Friday, the top play to make on this game is Clippers -2.5 at the spread.
Clippers vs. Grizzlies player props
NBA player props are an enjoyable way to wager on Friday's LA Clippers vs. Memphis game without necessarily betting on the outcome. We use the best information available to project how each team's leading players will perform at FedExForum.
James Harden is expected to lead the Clippers with 26 points, 6 rebounds and 9 assists, while Jaren Jackson is projected to have 20 points, 5 rebounds and 2 assists for the Grizzlies.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.
Clippers prediction
Our model's projected player stats for the Clippers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| James Harden | 26 | 6 | 9 | 4 | 54 |
| Kawhi Leonard | 24 | 5 | 3 | 2 | 41 |
| Ivica Zubac | 16 | 12 | 4 | 0 | 41 |
| John Collins | 15 | 6 | 1 | 1 | 30 |
| Kris Dunn | 9 | 3 | 3 | 2 | 22 |
Grizzlies prediction
Projected points, rebounds, assists and three-pointers made for the Grizzlies:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Jaren Jackson | 20 | 5 | 2 | 2 | 36 |
| Zach Edey | 13 | 12 | 2 | 0 | 36 |
| Cedric Coward | 13 | 6 | 3 | 2 | 27 |
| Jaylen Wells | 12 | 4 | 2 | 2 | 22 |
| Santi Aldama | 11 | 5 | 3 | 1 | 25 |
Clippers vs. Grizzlies game-day updates and essential details
Friday's action between the Grizzlies and Clippers at FedExForum is scheduled to commence at 8:00PM ET.
- Who: Los Angeles Clippers vs. Memphis Grizzlies
- Date: Friday, December 5, 2025
- Time: 8:00PM ET/5:00PM PT
- Venue: FedExForum
Conclusion
We predict the Clippers, with a 57% win probability, will likely beat the Grizzlies on Friday, with James Harden projected for a game-high 54 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Clippers vs. Grizzlies insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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