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Kansas vs. Iowa State prediction: Why Iowa State is favored to win in college football Week 13, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Kansas vs Iowa State predictions for college football Saturday.
Iowa State and Kansas will lock horns in Week 13 college football action at Jack Trice Stadium on Saturday, beginning at 12:00PM ET.
Based on updated simulations, Dimers' proven college football model predicts Iowa State as the most likely winner of the Kansas vs. Iowa State game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Kansas vs. Iowa State prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Kansas vs. Iowa State 10,000 times as part of our college football predictions coverage.
Our famous predictive model gives Iowa State a 62% chance of defeating Kansas. Our predicted final score has Iowa State winning 28-23.
According to our model, Iowa State (-3.5) has a 52% chance of covering the spread, while the 55.5-point over/under has a 60% chance of going over.
Kansas vs. Iowa State odds
We have researched the best College Football odds in America for this game, which are listed here:
| Bet Type | Kansas | Iowa State |
|---|---|---|
| Spread | +3.5 (-120) | -3.5 (-102) |
| Moneyline | +140 | -158 |
| Total | o55.5 (-108) | u55.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Kansas vs. Iowa State picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Iowa State -3.5 | -102 |
| Moneyline | Iowa State | -158 |
| Total | Over 55.5 | -108 |
According to our best college football bets, the top play to make on this game is Over 55.5 total points.
Kansas vs. Iowa State game-day updates and essential details
Saturday's college football game between Iowa State and Kansas at Jack Trice Stadium is scheduled to begin at 12:00PM ET.
- Who: Kansas vs. Iowa State
- Date: Saturday, November 22, 2025
- Time: 12:00PM ET/9:00AM PT
- Venue: Jack Trice Stadium
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Conclusion
We predict Iowa State, with a 62% win probability, will likely beat Kansas on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Kansas vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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