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Iowa State vs. BYU prediction: Iowa State favored to win men's college basketball matchup [2/21/2026]

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Written by Dave Garofolo

Get Iowa State vs BYU predictions for college basketball Saturday.

Iowa State-BYU Predictions and Game Preview.
Iowa State vs. BYU men's college basketball prediction for Saturday, February 21, 2026.

BYU will take on Iowa State in men's college basketball action at Marriott Center on Saturday, commencing at 10:30 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Iowa State as the most likely winner of the Iowa State vs. BYU game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Iowa State vs. BYU prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Saturday's NCAA basketball game between Iowa State and BYU 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Iowa State a 55% chance of beating BYU. Our predicted final score has Iowa State winning 79-78.

According to our model, BYU (+2.5) has a 56% chance of covering the spread, while the 154.5-point over/under has a 53% chance of going over.

 

Iowa State vs. BYU odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

Bet Type Iowa State BYU
Spread -2.5 (-115) +2.5 (-105)
Moneyline -108 +125
Total o154.5 (-110) u154.5 (-110)

All odds are correct at the time of publication and are subject to change.

Iowa State vs. BYU picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread BYU +2.5 -105
Moneyline Iowa State -108
Total Over 154.5 -110

According to our men's college basketball best bets, the top play to make on this game is BYU +2.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

 

Iowa State vs. BYU game-day updates and essential details

Saturday's men's college basketball game between BYU and Iowa State at Marriott Center is scheduled to start at 10:30 PM ET.

  • Who: Iowa State vs. BYU
  • Date: Saturday, February 21, 2026
  • Time: 10:30 PM ET/7:30PM PT
  • Venue: Marriott Center

Conclusion

We predict Iowa State, with a 55% win probability, will likely beat BYU on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Iowa State vs. BYU insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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