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Colts vs. Chargers prediction: Chargers favored to win in NFL Week 7, 2025
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Indianapolis Colts vs Los Angeles Chargers predictions for NFL Sunday.
The Los Angeles Chargers and Indianapolis Colts will lock horns in Week 7 of the NFL season at SoFi Stadium on Sunday, with kickoff at 4:05PM ET.
Based on updated simulation results, Dimers' advanced NFL model projects the Chargers as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's Colts-Chargers game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Chargers with a win probability of 57%, while the Colts have 43%."
This gameday Colts vs. Chargers betting preview builds on my Colts vs. Chargers prediction that was posted earlier in the week.
For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Colts vs. Chargers predictions page.
Colts vs. Chargers predictions
Since our Colts-Chargers predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Colts and Chargers 10,000 times as part of our NFL predictions coverage.
Our leading predictive model gives the Chargers a 57% chance of beating the Colts in Week 7 of the NFL season. Our predicted final score has the Chargers winning 25-23.
According to our model, the Colts (+2.5) have a 58% chance of covering the spread, while the 48.5-point over/under has an equal 50-50 chance of hitting.
To see win probabilities for every matchup this week, check out our expert NFL Week 7 straight up picks.
Colts vs. Chargers odds
We have sourced the best NFL odds in America for this game, which are listed here:
| Bet Type | Colts | Chargers |
|---|---|---|
| Spread | +2.5 (-105) | -2.5 (-110) |
| Moneyline | +120 | -135 |
| Total | o48.5 (-110) | u48.5 (-108) |
All odds are correct at the time of publication and are subject to change.
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Colts vs. Chargers picks and best bets
Our model's biggest edge in today's Colts vs. Chargers matchup is on the total.
Our expert predictions, aligned with the latest odds, reveal the best NFL picks and NFL best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Colts vs. Chargers TD scorers
Who will score the first touchdown in Colts vs. Chargers?
According to our list of touchdown scorer predictions for today, Indianapolis' Jonathan Taylor is most likely to score the first TD in Colts vs. Chargers.
Our projections give Taylor a 15.4% chance of getting in for six first at SoFi Stadium, while the Colts running back is a 58.6% chance of registering an anytime touchdown.
First touchdown scorer predictions
Indianapolis Colts
| Player | First TD Probability |
|---|---|
| Jonathan Taylor (RB) | 15.4% |
| Tyler Warren (TE) | 7.0% |
| Michael Pittman (WR) | 5.7% |
Los Angeles Chargers
| Player | First TD Probability |
|---|---|
| Kimani Vidal (RB) | 9.2% |
| Hassan Haskins (RB) | 7.4% |
| Quentin Johnston (WR) | 7.3% |
Anytime touchdown scorer predictions
Indianapolis Colts
| Player | Anytime TD Probability |
|---|---|
| Jonathan Taylor (RB) | 58.6% |
| Tyler Warren (TE) | 33.2% |
| Michael Pittman (WR) | 28.1% |
Los Angeles Chargers
| Player | Anytime TD Probability |
|---|---|
| Kimani Vidal (RB) | 40.3% |
| Hassan Haskins (RB) | 33.8% |
| Quentin Johnston (WR) | 33.6% |
Colts vs Chargers player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Colts and Chargers. For detailed projections, join Dimers Pro.
Already a Dimers Pro member? Head to our NFL player projections page now to access player prop projections for every offensive player in this matchup and all other Week 7 games.
Colts vs. Chargers quarterbacks
Of the starting quarterbacks, the Colts' Daniel Jones is projected to throw for fewer yards than the Chargers' Justin Herbert.
Colts rushing
Jonathan Taylor, Daniel Jones and DJ Giddens are projected to be the leading rushers for the Colts.
| Player | Position |
|---|---|
| Jonathan Taylor | RB |
| Daniel Jones | QB |
| DJ Giddens | RB |
Chargers rushing
Kimani Vidal, Hassan Haskins and Justin Herbert are expected to lead the Chargers in rushing yards.
| Player | Position |
|---|---|
| Kimani Vidal | RB |
| Hassan Haskins | RB |
| Justin Herbert | QB |
Colts receiving
Tyler Warren, Michael Pittman, Alec Pierce, Adonai Mitchell and Jonathan Taylor are projected to top the receiving yards for the Colts.
| Player | Position |
|---|---|
| Tyler Warren | TE |
| Michael Pittman | WR |
| Alec Pierce | WR |
| Adonai Mitchell | WR |
| Jonathan Taylor | RB |
Chargers receiving
Ladd McConkey, Quentin Johnston, Keenan Allen, Oronde Gadsden and Kimani Vidal are projected to lead the Chargers in receiving yards.
| Player | Position |
|---|---|
| Ladd McConkey | WR |
| Quentin Johnston | WR |
| Keenan Allen | WR |
| Oronde Gadsden | TE |
| Kimani Vidal | RB |
Colts vs. Chargers game-day updates and essential details
The NFL Week 7 action between the Chargers and Colts at SoFi Stadium is scheduled to start at 4:05PM ET.
- Who: Indianapolis Colts vs. Los Angeles Chargers
- Date: Sunday, October 19, 2025
- Time: 4:05PM ET/1:05PM PT
- Venue: SoFi Stadium
Dimers' comprehensive preview of this week's Colts vs. Chargers matchup includes our prediction, picks and the latest betting odds.
Before making any Colts vs. Chargers picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.
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Conclusion
We predict the Chargers, with a 57% win probability, will likely beat the Colts in Week 7 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Colts vs. Chargers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on NFL
Keep up with the latest NFL betting news and NFL parlay picks throughout the season. Plus, our Super Bowl odds offer the latest probabilities for the Super Bowl, AFC, NFC and each division.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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