Colts vs. Jaguars prediction: Indianapolis favored to win in NFL Week 14, 2025

The Jacksonville Jaguars will take on the Indianapolis Colts in NFL Week 14 action at EverBank Stadium on Sunday, starting at 1:00PM ET.

Based on updated simulation results, Dimers' proven NFL model predicts the Colts as the most likely winner of the Colts vs. Jaguars game.

This article offers further insights into this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Colts vs. Jaguars prediction: Who will win and cover?

Since our Colts-Jaguars predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Colts and Jaguars 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Colts a 56% chance of defeating the Jaguars in Week 14 of the NFL season. Our predicted final score has the Colts winning 23-21.

According to our model, the Jaguars (+2.5) have a 58% chance of covering the spread, while the over/under total of 45.5 points has a 53% chance of staying under.

To see win probabilities for every matchup this week, check out our expert NFL Week 14 straight up picks.

Colts vs. Jaguars odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Colts	Jaguars
Spread	-2.5 (-112)	+2.5 (-108)
Moneyline	-135	+122
Total	o45.5 (-110)	u45.5 (-110)

All odds are correct at the time of publication and are subject to change.

Colts vs. Jaguars picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Jaguars +2.5	-108
Moneyline	Colts	-135
Total	Under 45.5	-110

According to our NFL best bets, the top play to make on this game is Jaguars +2.5 at the spread.

Colts vs. Jaguars TD scorers

Who will score a touchdown in Colts vs. Jaguars?

According to our list of touchdown scorer predictions for today, Jonathan Taylor is most likely to score an anytime TD in Colts vs. Jaguars.

Our projections give Taylor a 64.5% chance of scoring a TD at EverBank Stadium, while the running back is a 19.1% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Indianapolis Colts

Player	Anytime TD Probability
Jonathan Taylor (RB)	64.5%
Tyler Warren (TE)	31.2%
Michael Pittman (WR)	29.0%
Alec Pierce (WR)	26.2%
Josh Downs (WR)	21.8%

Jacksonville Jaguars

Player	Anytime TD Probability
Travis Etienne (RB)	39.5%
Bhayshul Tuten (RB)	31.1%
Jakobi Meyers (WR)	28.9%
Brian Thomas (WR)	26.7%
Brenton Strange (TE)	21.9%

First touchdown scorer predictions

Indianapolis Colts

Player	First TD Probability
Jonathan Taylor (RB)	19.1%
Tyler Warren (TE)	6.9%
Michael Pittman (WR)	6.3%
Alec Pierce (WR)	5.6%
Josh Downs (WR)	4.5%

Jacksonville Jaguars

Player	First TD Probability
Travis Etienne (RB)	9.3%
Bhayshul Tuten (RB)	6.9%
Jakobi Meyers (WR)	6.4%
Brian Thomas (WR)	5.8%
Brenton Strange (TE)	4.6%

Colts vs Jaguars player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Colts and Jaguars. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 14 games.

Quarterbacks

Of the starting quarterbacks, the Colts' Daniel Jones is projected for 225 passing yards. The Jaguars' Trevor Lawrence is expected to throw for 218 yards.

Player	Proj. Pass Yards
Daniel Jones (IND)	225
Trevor Lawrence (JAX)	218

Colts rushing

Player	Proj. Rush Yards
Jonathan Taylor	95
Daniel Jones	10
Ameer Abdullah	6

Jaguars rushing

Player	Proj. Rush Yards
Travis Etienne	53
Bhayshul Tuten	28
Trevor Lawrence	18

Colts receiving

Player	Proj. Rec. Yards
Alec Pierce	56
Michael Pittman	52
Tyler Warren	50
Josh Downs	39
Jonathan Taylor	20

Jaguars receiving

Player	Proj. Rec. Yards
Jakobi Meyers	56
Brian Thomas	48
Brenton Strange	43
Tim Patrick	18
Austin Trammell	17

Colts vs. Jaguars game-day updates and essential details

The NFL Week 14 game between the Jaguars and Colts at EverBank Stadium is scheduled to start at 1:00PM ET.

• Who: Indianapolis Colts vs. Jacksonville Jaguars
• Date: Sunday, December 7, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: EverBank Stadium

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Conclusion

We predict the Colts, with a 56% win probability, will likely beat the Jaguars in Week 14 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Colts vs. Jaguars insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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