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Indiana State vs. Southern Illinois prediction: Southern Illinois favored to win men's college basketball matchup [2/25/2026]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Indiana State vs Southern Illinois predictions for college basketball Wednesday.
Southern Illinois and Indiana State will meet in men's college basketball action at Banterra Center on Wednesday, starting at 8:00 PM ET.
Based on the latest simulation results, Dimers' advanced college basketball model predicts Southern Illinois as the most likely winner of the Indiana State vs. Southern Illinois game.
This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
Indiana State vs. Southern Illinois prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball matchup between Indiana State and Southern Illinois 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives Southern Illinois a 77% chance of defeating Indiana State. Our predicted final score has Southern Illinois winning 78-70.
According to our model, the bookies have got it right, and Indiana State and Southern Illinois each have a 50% chance of covering the spread, while the 146.5-point over/under also has an equal 50-50 chance of hitting.
Indiana State vs. Southern Illinois odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Indiana State | Southern Illinois |
|---|---|---|
| Spread | +8.5 (-110) | -8.5 (-102) |
| Moneyline | +330 | -375 |
| Total | o146.5 (-115) | u146.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Indiana State vs. Southern Illinois picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Southern Illinois -8.5 | -102 |
| Moneyline | Indiana State | +330 |
| Total | Under 146.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Indiana State to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Indiana State vs. Southern Illinois game-day updates and essential details
Wednesday's men's college basketball action between Southern Illinois and Indiana State at Banterra Center is scheduled to commence at 8:00 PM ET.
- Who: Indiana State vs. Southern Illinois
- Date: Wednesday, February 25, 2026
- Time: 8:00 PM ET/5:00PM PT
- Venue: Banterra Center
Conclusion
We predict Southern Illinois, with a 77% win probability, will likely beat Indiana State on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Indiana State vs. Southern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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