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Pacers vs. 76ers prediction: Why Philadelphia is favored to win Friday's NBA matchup [12/12/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Indiana Pacers vs Philadelphia 76ers predictions for NBA Friday.
The Philadelphia 76ers and Indiana Pacers will lock horns in NBA action at Xfinity Mobile Arena on Friday, starting at 7:00PM ET.
Based on updated simulations and today’s injury updates, Dimers' advanced NBA model predicts the 76ers as the most likely winner of the Pacers vs. 76ers game.
This prediction follows the latest NBA Injury Report, which suggests the 76ers lineup will feature players like Tyrese Maxey, Joel Embiid and Quentin Grimes, while the Pacers will look to Pascal Siakam, Bennedict Mathurin and Andrew Nembhard.
This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Sixers vs. Sixers prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Friday's NBA matchup between the Pacers and 76ers 10,000 times as part of our NBA predictions coverage.
Our independent predictive model gives the 76ers a 71% chance of beating the Pacers. Our predicted final score has the 76ers winning 115-109.
According to our model, the Pacers (+7) have a 53% chance of covering the spread, while the 224.5-point over/under has a 51% chance of staying under.
Pacers vs. 76ers odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Pacers | 76ers |
|---|---|---|
| Spread | +7 (-110) | -7 (-110) |
| Moneyline | +235 | -285 |
| Total | o224.5 (-108) | u224.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Pacers vs. 76ers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Pacers +7 | -110 |
| Moneyline | Pacers | +235 |
| Total | Under 224.5 | -110 |
According to our best NBA bets for Friday, the top play to make on this game is Pacers +7 at the spread.
Pacers vs. 76ers player props
NBA player props are an exciting way to wager on the Indiana vs. Philadelphia matchup without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Xfinity Mobile Arena.
Pascal Siakam is expected to lead the Pacers with 23 points, 7 rebounds and 4 assists, while Tyrese Maxey is projected to have 26 points, 4 rebounds and 6 assists for the 76ers.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
Pacers prediction
Our model's projected player stats for the Pacers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Pascal Siakam | 23 | 7 | 4 | 2 | 44 |
| B. Mathurin | 21 | 6 | 3 | 2 | 37 |
| Andrew Nembhard | 15 | 3 | 6 | 2 | 33 |
| Jay Huff | 12 | 5 | 2 | 3 | 30 |
| T.J. McConnell | 9 | 3 | 4 | 0 | 22 |
76ers prediction
Projected points, rebounds, assists and three-pointers made for the 76ers:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Tyrese Maxey | 26 | 4 | 6 | 3 | 48 |
| Joel Embiid | 22 | 7 | 4 | 1 | 43 |
| Quentin Grimes | 16 | 4 | 4 | 2 | 33 |
| Paul George | 16 | 5 | 3 | 2 | 33 |
| VJ Edgecombe | 13 | 6 | 3 | 2 | 30 |
Pacers vs. Sixers game-day updates and essential details
Friday's matchup between the 76ers and Pacers at Xfinity Mobile Arena is scheduled to start at 7:00PM ET.
- Who: Indiana Pacers vs. Philadelphia 76ers
- Date: Friday, December 12, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: Xfinity Mobile Arena
Conclusion
We predict the 76ers, with a 71% win probability, will likely beat the Pacers on Friday, with Tyrese Maxey projected for a game-high 48 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Pacers vs. 76ers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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