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Pacers vs. 76ers prediction: Why Philadelphia is favored to win Friday's NBA matchup [12/12/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Indiana Pacers vs Philadelphia 76ers predictions for NBA Friday.
NBA action continues on Friday at 7:00PM ET as the Indiana Pacers lock horns with the Philadelphia 76ers at Xfinity Mobile Arena.
Based on updated simulation results and today’s injury reports, Dimers' proven NBA model predicts the 76ers as the most likely winner of the Pacers vs. 76ers game.
This prediction follows the latest NBA Injury Report, which suggests the 76ers lineup will feature stars like Joel Embiid, Quentin Grimes and Paul George, while the Pacers will rely on Pascal Siakam, Bennedict Mathurin and Andrew Nembhard.
This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Sixers vs. Sixers prediction: Who will win and cover?
Using trusted machine learning and statistical analysis, we have simulated the outcome of Friday's NBA game between the Pacers and 76ers 10,000 times as part of our NBA predictions coverage.
Our leading predictive model gives the 76ers a 69% chance of beating the Pacers. Our predicted final score has the 76ers winning 113-107.
According to our model, the 76ers (-5.5) have a 51% chance of covering the spread, while the over/under total of 221.5 points has a 52% chance of staying under.
Pacers vs. 76ers odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Pacers | 76ers |
|---|---|---|
| Spread | +5.5 (-105) | -5.5 (-108) |
| Moneyline | +190 | -225 |
| Total | o221.5 (-108) | u221.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Pacers vs. 76ers picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | 76ers -5.5 | -108 |
| Moneyline | 76ers | -225 |
| Total | Under 221.5 | -110 |
According to our best NBA bets for Friday, the top play to make on this game is 76ers to win.
Pacers vs. 76ers player props
Betting on Indiana vs. Philadelphia NBA prop bets? We use the best information available to project how each team's leading players will perform at Xfinity Mobile Arena.
Pascal Siakam is expected to lead the Pacers with 23 points, 7 rebounds and 4 assists, while Joel Embiid is projected to have 23 points, 7 rebounds and 4 assists for the 76ers.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
Pacers prediction
Our model's projected player stats for the Pacers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Pascal Siakam | 23 | 7 | 4 | 2 | 45 |
| B. Mathurin | 21 | 6 | 3 | 2 | 37 |
| Andrew Nembhard | 15 | 4 | 6 | 2 | 34 |
| Jay Huff | 12 | 5 | 2 | 3 | 30 |
| T.J. McConnell | 8 | 3 | 4 | 0 | 21 |
76ers prediction
Projected points, rebounds, assists and three-pointers made for the 76ers:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Joel Embiid | 23 | 7 | 4 | 1 | 43 |
| Quentin Grimes | 18 | 5 | 4 | 3 | 37 |
| Paul George | 17 | 5 | 4 | 2 | 35 |
| Jared McCain | 16 | 3 | 3 | 2 | 28 |
| VJ Edgecombe | 14 | 6 | 4 | 2 | 33 |
Pacers vs. Sixers game-day updates and essential details
Friday's matchup between the 76ers and Pacers at Xfinity Mobile Arena is scheduled to start at 7:00PM ET.
- Who: Indiana Pacers vs. Philadelphia 76ers
- Date: Friday, December 12, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: Xfinity Mobile Arena
Conclusion
We predict the 76ers, with a 69% win probability, will likely beat the Pacers on Friday, with Pascal Siakam projected for a game-high 45 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Pacers vs. 76ers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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