Astros vs. Angels Prediction: Tight Battle Projected in Updated Analysis for Sunday's MLB Matchup [6/22/2025]

MLB action continues on Sunday at 4:07PM ET as the Houston Astros take on the Los Angeles Angels at Angel Stadium.

Kyle Hendricks (5-6, 4.79 ERA) will get the ball for the Angels, up against Ryan Gusto (4-3, 4.31 ERA) for the Astros.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects an equal chance for both the Angels and Astros to win today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Astros-Angels game," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Angels and Astros, making it a highly competitive matchup."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Astros vs. Angels predictions page.

Angels vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the outcome of Sunday's MLB game between the Astros and Angels 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently can't split the two teams, giving both the Astros and Angels a 50% chance of winning the game.

According to our model, the Angels (+1.5) have a 61% chance of covering the run line, while the 8.5-run over/under has a 54% chance of going over.

Astros vs. Angels Odds [6/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Astros	Angels
Run Line	-1.5 (+154)	+1.5 (-178)
Moneyline	-110	-104
Total	o8.5 (-115)	u8.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Astros vs. Angels Picks and Best Bets

Our model's biggest edge in today's Astros vs. Angels matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Astros vs. Angels Game-Day Updates and Essential Details

Sunday's MLB game between the Angels and Astros at Angel Stadium is scheduled to commence at 4:07PM ET.

• Who: Houston Astros vs. Los Angeles Angels
• Date: Sunday, June 22, 2025
• Time: 4:07PM ET/1:07PM PT
• Venue: Angel Stadium

Dimers.com's full preview of Sunday's Astros vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Astros vs. Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict a close game between the Astros and Angels on Sunday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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