Astros vs. Rockies prediction: Why Colorado is favored to win Wednesday's MLB matchup [4/8/2026]

The Colorado Rockies will face the Houston Astros in MLB action at Coors Field on Wednesday, beginning at 3:10 PM ET.

Michael Lorenzen (0-1, 14.73 ERA) will be the starting pitcher for the Rockies, while the Astros are going with Cristian Javier (0-1, 12.96 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Rockies as the most likely winner of the Astros vs. Rockies game.

This article offers further insights into Wednesday's matchup, including best bets and picks.

Astros vs. Rockies prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's MLB matchup between the Astros and Rockies, forming part of our MLB predictions coverage.

Our independent predictive model currently gives the Rockies a 59% chance of defeating the Astros.

According to our model, the Rockies (+1.5) have a 54% chance of covering the run line, while the 11-run over/under has a 56% chance of going over.

Astros vs. Rockies odds [4/8/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Astros vs. Rockies picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: