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Panthers vs. Sabres prediction: Florida favored to win Saturday's NHL matchup [10/18/2025]
Updated: | First published:
Written by Nick Slade, Chief Content Officer
Get Florida Panthers vs Buffalo Sabres predictions for NHL Saturday.
The Buffalo Sabres and Florida Panthers will lock horns in the NHL at KeyBank Center on Saturday, starting at 1:00PM ET.
Based on the latest simulations, Dimers' advanced NHL model projects the Panthers as the most likely winner of today's game.
For expanded analysis of Saturday's matchup, including best bets and player prop picks, visit our interactive Panthers vs. Sabres predictions page.
Panthers vs. Sabres prediction: Who will win, cover the puck line?
Using powerful machine learning and data, we have simulated the result of Saturday's NHL game between the Panthers and Sabres 10,000 times as part of our NHL predictions coverage.
Our leading predictive model gives the Panthers a 58% chance of defeating the Sabres.
According to our model, the Sabres (+1.5) have a 64% chance of covering the puck line, while the over/under total of 6 goals has a 52% chance of going over.
Panthers vs. Sabres odds
We have sourced the best NHL odds in America for this game, which are listed here:
| Bet Type | Panthers | Sabres |
|---|---|---|
| Puck Line | -1.5 (+164) | +1.5 (-190) |
| Moneyline | -150 | +130 |
| Total | o6 (-110) | u6 (-110) |
All odds are correct at the time of publication and are subject to change.
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Panthers vs. Sabres picks and best bets
Our model's strongest edge in today's Panthers vs. Sabres matchup is on the puck line.
Our expert predictions, matched against the best odds, reveal the best NHL picks and NHL best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Panthers vs. Sabres player props
Who will score an anytime goal in Panthers vs. Sabres?
According to our model, Florida's Sam Reinhart is most likely to score the first goal in Panthers vs. Sabres.
Our projections give Reinhart an 8.8% chance of scoring the first goal at KeyBank Center, while the Panthers star is a 42.8% chance of netting an anytime goal.
First goal scorer predictions
Florida Panthers
| Player | First Goal Probability |
|---|---|
| Sam Reinhart | 8.8% |
| Sam Bennett | 6.1% |
| Brad Marchand | 5.5% |
Buffalo Sabres
| Player | First Goal Probability |
|---|---|
| Tage Thompson | 7.7% |
| Alex Tuch | 6.6% |
| Jason Zucker | 4.5% |
Anytime goal scorer predictions
Florida Panthers
| Player | Anytime Goal Probability |
|---|---|
| Sam Reinhart | 42.8% |
| Sam Bennett | 31.7% |
| Brad Marchand | 31.0% |
Buffalo Sabres
| Player | Anytime Goal Probability |
|---|---|
| Tage Thompson | 39.1% |
| Alex Tuch | 31.8% |
| Jason Zucker | 24.4% |
Panthers vs. Sabres game-day updates and essential details
Saturday's matchup between the Sabres and Panthers at KeyBank Center is scheduled to start at 1:00PM ET.
- Who: Florida Panthers vs. Buffalo Sabres
- Date: Saturday, October 18, 2025
- Time: 1:00PM ET/10:00AM PT
- Venue: KeyBank Center
Dimers' full preview of Saturday's Panthers vs. Sabres matchup includes our prediction, picks and the latest betting odds.
Before making any Panthers vs. Sabres picks, be sure to check out the latest NHL predictions and betting advice from Dimers Pro.
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Conclusion
We predict the Panthers, with a 58% win probability, will likely beat the Sabres on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Panthers vs. Sabres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on NHL
Stay up-to-date with the latest NHL betting news and parlay picks throughout the season. Plus, our Stanley Cup odds provide the latest predictions for the Stanley Cup title.
Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.
Nick Slade, with nearly two decades of experience, is the Chief Content Officer at Cipher Sports Technology Group, overseeing content for Dimers. He specializes in soccer, NBA, and NHL betting, leveraging predictive analytics and machine learning to provide accurate betting insights.
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