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Eastern Kentucky vs. Louisville prediction: Louisville favored to win women's college basketball matchup [12/17/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Eastern Kentucky vs Louisville predictions for college basketball Wednesday.
Louisville will take on Eastern Kentucky in women's college basketball action at KFC Yum! Center on Wednesday, starting at 6:00 PM ET.
Based on updated simulation results, Dimers' new women's basketball model predicts Louisville as the most likely winner of the Eastern Kentucky vs. Louisville game.
This article offers a closer look at Wednesday's matchup, including best bets and picks.
Eastern Kentucky vs. Louisville prediction: Who will win?
Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's women's basketball matchup between Eastern Kentucky and Louisville 10,000 times as part of our women's college basketball predictions coverage.
Our independent predictive model gives Louisville a 99% chance of beating Eastern Kentucky.
According to our model, the 140.5-point over/under has a 51% chance of staying under.
Eastern Kentucky vs. Louisville odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Eastern Kentucky | Louisville |
|---|---|---|
| Spread | +39.5 (-106) | -39.5 (-114) |
| Total | o140.5 (-110) | u140.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Eastern Kentucky vs. Louisville picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Eastern Kentucky +39.5 | -106 |
| Total | Under 140.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Eastern Kentucky +39.5.
Eastern Kentucky vs. Louisville game-day updates and essential details
Wednesday's women's basketball game between Louisville and Eastern Kentucky at KFC Yum! Center is scheduled to commence at 6:00 PM ET.
- Who: Eastern Kentucky vs. Louisville
- Date: Wednesday, December 17, 2025
- Time: 6:00 PM ET/3:00PM PT
- Venue: KFC Yum! Center
Conclusion
We predict Louisville, with a 99% win probability, will likely beat Eastern Kentucky on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Eastern Kentucky vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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