Eastern Kentucky vs. Louisville prediction: Louisville favored to win women's college basketball matchup [12/17/2025]

Women's college basketball action continues on Wednesday at 6:00 PM ET as Eastern Kentucky takes on Louisville at KFC Yum! Center.

Based on updated simulation results, Dimers' new women's basketball model predicts Louisville as the most likely winner of the Eastern Kentucky vs. Louisville game.

This article offers a closer look at Wednesday's matchup, including best bets and picks.

Eastern Kentucky vs. Louisville prediction: Who will win?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's women's basketball matchup between Eastern Kentucky and Louisville 10,000 times as part of our women's college basketball predictions coverage.

Our famous predictive model gives Louisville a 99% chance of defeating Eastern Kentucky.

According to our model, the 140.5-point over/under has a 51% chance of staying under.

Eastern Kentucky vs. Louisville odds

We have sourced the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Eastern Kentucky vs. Louisville picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: