Duke vs. Syracuse prediction: Duke favored to win women's college basketball matchup [12/28/2025]

Syracuse and Duke will lock horns in the women's college basketball at JMA Wireless Dome on Sunday, starting at 4:00 PM ET.

Based on updated simulation results, Dimers' new women's basketball model projects Duke as the most likely winner of the Duke vs. Syracuse game.

This article offers further insights into Sunday's matchup, including best bets and picks.

Duke vs. Syracuse prediction: Who will win?

Using innovative machine learning and data, we have simulated the result of Sunday's women's basketball game between Duke and Syracuse 10,000 times as part of our women's college basketball predictions coverage.

Our famous predictive model currently gives Duke a 94% chance of beating Syracuse.

According to our model, the over/under total of 133.5 points has a 59% chance of staying under.

Duke vs. Syracuse odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Duke vs. Syracuse picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: