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Duke vs. Syracuse prediction: Duke favored to win women's college basketball matchup [12/28/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Duke vs Syracuse predictions for college basketball Sunday.
Syracuse and Duke will lock horns in the women's college basketball at JMA Wireless Dome on Sunday, starting at 4:00 PM ET.
Based on updated simulation results, Dimers' new women's basketball model projects Duke as the most likely winner of the Duke vs. Syracuse game.
This article offers further insights into Sunday's matchup, including best bets and picks.
Duke vs. Syracuse prediction: Who will win?
Using innovative machine learning and data, we have simulated the result of Sunday's women's basketball game between Duke and Syracuse 10,000 times as part of our women's college basketball predictions coverage.
Our famous predictive model currently gives Duke a 94% chance of beating Syracuse.
According to our model, the over/under total of 133.5 points has a 59% chance of staying under.
Duke vs. Syracuse odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Duke | Syracuse |
|---|---|---|
| Spread | -8.5 (-110) | +8.5 (-110) |
| Moneyline | -395 | +310 |
| Total | o133.5 (-110) | u133.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Duke vs. Syracuse picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Duke -8.5 | -110 |
| Moneyline | Duke | -395 |
| Total | Under 133.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Duke to win.
Duke vs. Syracuse game-day updates and essential details
Sunday's women's basketball game between Syracuse and Duke at JMA Wireless Dome is scheduled to start at 4:00 PM ET.
- Who: Duke vs. Syracuse
- Date: Sunday, December 28, 2025
- Time: 4:00 PM ET/1:00PM PT
- Venue: JMA Wireless Dome
Conclusion
We predict Duke, with a 94% win probability, will likely beat Syracuse on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Duke vs. Syracuse insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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