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Duke vs. Notre Dame prediction: Duke favored to win men's college basketball matchup [2/24/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Duke vs Notre Dame predictions for college basketball Tuesday.
Notre Dame will take on the favored Duke in men's college basketball action at Purcell Pavilion on Tuesday, starting at 7:00 PM ET.
Based on updated simulation results, Dimers' proven college basketball model predicts Duke as the most likely winner of the Duke vs. Notre Dame game.
This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.
Duke vs. Notre Dame prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the outcome of Tuesday's NCAA basketball game between Duke and Notre Dame 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model gives Duke a 92% chance of defeating Notre Dame. Our predicted final score has Duke winning 78-63.
According to our model, Notre Dame (+20.5) has a 59% chance of covering the spread, while the 142.5-point over/under has a 51% chance of staying under.
Duke vs. Notre Dame odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Duke | Notre Dame |
|---|---|---|
| Spread | -20.5 (-110) | +20.5 (-118) |
| Moneyline | -2500 | +1500 |
| Total | o142.5 (-105) | u142.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Duke vs. Notre Dame picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Notre Dame +20.5 | -118 |
| Moneyline | Notre Dame | +1500 |
| Total | Over 142.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Notre Dame +20.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Duke vs. Notre Dame game-day updates and essential details
Tuesday's men's college basketball action between Notre Dame and Duke at Purcell Pavilion is scheduled to begin at 7:00 PM ET.
- Who: Duke vs. Notre Dame
- Date: Tuesday, February 24, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: Purcell Pavilion
Conclusion
We predict Duke, with a 92% win probability, will likely beat Notre Dame on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate Duke vs. Notre Dame insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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