Duke vs. LSU prediction: LSU favored to win women's March Madness Sweet Sixteen matchup [3/27/2026]

LSU and Duke are scheduled to meet in women's March Madness Sweet Sixteen action at Golden 1 Center on Friday, with tipoff at 10:00 PM ET.

Based on the latest simulations, Dimers' new women's basketball model predicts LSU as the most likely winner of the Duke vs. LSU game.

This article offers an expanded analysis of Friday's matchup, including best bets and picks.

Duke vs. LSU prediction: Who will win and advance to the Elite Eight?

Using powerful machine learning and data, we have simulated the outcome of Friday's NCAAW Tournament matchup between Duke and LSU, forming part of our women's college basketball predictions coverage.

Our independent predictive model gives LSU a 76% chance of defeating Duke.

According to our model, the 145.5-point over/under has a 51% chance of staying under.

Duke vs. LSU odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Duke vs. LSU picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best women's college basketball bets, the top play to make on this game is Duke to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Duke vs. LSU game-day updates and essential details

Friday's women's basketball action between LSU and Duke at Golden 1 Center is scheduled to start at 10:00 PM ET.

• Who: Duke vs. LSU
• Date: Friday, March 27, 2026
• Time: 10:00 PM ET/7:00PM PT
• Venue: Golden 1 Center
• March Madness stage: Sweet 16

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Conclusion

We predict LSU, with a 76% win probability, will likely beat Duke this women's March Madness Sweet Sixteen matchup.

AI and automation have enhanced this article to quickly deliver accurate Duke vs. LSU insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.

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