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Duke vs. Louisville prediction: Duke favored to win women's college basketball matchup [2/5/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Duke vs Louisville predictions for college basketball Thursday.
Women's college basketball action continues on Thursday at 7:00 PM ET as Duke locks horns with Louisville at KFC Yum! Center.
Based on the latest simulations, Dimers' new women's basketball model projects Duke as the most likely winner of the Duke vs. Louisville game.
This article offers a closer look at Thursday's matchup, including best bets and picks.
Duke vs. Louisville prediction: Who will win?
Using powerful machine learning and data analysis, we have simulated the outcome of Thursday's women's basketball matchup between Duke and Louisville 10,000 times as part of our women's college basketball predictions coverage.
Our independent predictive model gives Duke a 69% chance of defeating Louisville.
According to our model, the over/under total of 139.5 points has a 65% chance of staying under.
Duke vs. Louisville odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Duke | Louisville |
|---|---|---|
| Spread | +2.5 (-110) | -2.5 (-110) |
| Moneyline | +124 | -148 |
| Total | o139.5 (-110) | u139.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Duke vs. Louisville picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Duke +2.5 | -110 |
| Moneyline | Duke | +124 |
| Total | Under 139.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Duke to win.
Duke vs. Louisville game-day updates and essential details
Thursday's women's basketball matchup between Louisville and Duke at KFC Yum! Center is scheduled to commence at 7:00 PM ET.
- Who: Duke vs. Louisville
- Date: Thursday, February 5, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: KFC Yum! Center
Conclusion
We predict Duke, with a 69% win probability, will likely beat Louisville on Thursday.
AI and automation have enhanced this article to quickly deliver accurate Duke vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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