Duke vs. Louisville prediction: Duke favored to win women's college basketball matchup [2/5/2026]

Women's college basketball action continues on Thursday at 7:00 PM ET as Duke locks horns with Louisville at KFC Yum! Center.

Based on the latest simulation results, Dimers' new women's basketball model predicts Duke as the most likely winner of the Duke vs. Louisville game.

This article offers a closer look at Thursday's matchup, including best bets and picks.

Duke vs. Louisville prediction: Who will win?

Using innovative machine learning and data analysis, we have simulated the result of Thursday's women's basketball game between Duke and Louisville 10,000 times as part of our women's college basketball predictions coverage.

Our leading predictive model gives Duke a 67% chance of defeating Louisville.

According to our model, the over/under total of 139.5 points has a 65% chance of staying under.

Duke vs. Louisville odds

We have sourced the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Duke vs. Louisville picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: