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Duke vs. Clemson prediction: Why Duke is favored to win women's basketball matchup [2/22/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Duke vs Clemson predictions for college basketball Sunday.
Women's college basketball action continues on Sunday at 2:00 PM ET as the favored Duke locks horns with Clemson at Littlejohn Coliseum.
Based on the latest simulation results, Dimers' new women's basketball model predicts Duke as the most likely winner of the Duke vs. Clemson game.
This article offers an expanded analysis of Sunday's matchup, including best bets and picks.
Duke vs. Clemson prediction: Who will win?
Using powerful machine learning and data, we have simulated the result of Sunday's women's basketball matchup between Duke and Clemson 10,000 times as part of our women's college basketball predictions coverage.
Our leading predictive model currently gives Duke a 93% chance of defeating Clemson.
According to our model, the over/under total of 128.5 points has a 52% chance of staying under.
Duke vs. Clemson odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Duke | Clemson |
|---|---|---|
| Spread | -12.5 (-110) | +12.5 (-110) |
| Moneyline | -901 | +640 |
| Total | o128.5 (-110) | u128.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Duke vs. Clemson picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Duke -12.5 | -110 |
| Moneyline | Duke | -901 |
| Total | Under 128.5 | -110 |
According to our best women's college basketball bets, the top play to make on this game is Duke to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Duke vs. Clemson game-day updates and essential details
Sunday's women's basketball action between Clemson and Duke at Littlejohn Coliseum is scheduled to start at 2:00 PM ET.
- Who: Duke vs. Clemson
- Date: Sunday, February 22, 2026
- Time: 2:00 PM ET/11:00AM PT
- Venue: Littlejohn Coliseum
Conclusion
We predict Duke, with a 93% win probability, will likely beat Clemson on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Duke vs. Clemson insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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