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DePaul vs. Creighton prediction: Why Creighton is favored to win men's college basketball matchup [2/25/2026]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get DePaul vs Creighton predictions for college basketball Wednesday.
Creighton will face DePaul in men's college basketball action at CHI Health Center Omaha on Wednesday, beginning at 9:00 PM ET.
Based on updated simulation results, Dimers' proven college basketball model predicts Creighton as the most likely winner of the DePaul vs. Creighton game.
This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
DePaul vs. Creighton prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's NCAA basketball game between DePaul and Creighton 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model gives Creighton a 66% chance of beating DePaul. Our predicted final score has Creighton winning 75-70.
According to our model, Creighton (-3.5) has a 51% chance of covering the spread, while the 143.5-point over/under has a 55% chance of going over.
DePaul vs. Creighton odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | DePaul | Creighton |
|---|---|---|
| Spread | +3.5 (-102) | -3.5 (-118) |
| Moneyline | +168 | -190 |
| Total | o143.5 (-105) | u143.5 (-115) |
All odds are correct at the time of publication and are subject to change.
DePaul vs. Creighton picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | DePaul +3.5 | -102 |
| Moneyline | Creighton | -190 |
| Total | Over 143.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Over 143.5 total points.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
DePaul vs. Creighton game-day updates and essential details
Wednesday's men's college basketball action between Creighton and DePaul at CHI Health Center Omaha is scheduled to commence at 9:00 PM ET.
- Who: DePaul vs. Creighton
- Date: Wednesday, February 25, 2026
- Time: 9:00 PM ET/6:00PM PT
- Venue: CHI Health Center Omaha
Conclusion
We predict Creighton, with a 66% win probability, will likely beat DePaul on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate DePaul vs. Creighton insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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