Blue Jackets vs. Sabres prediction: Buffalo favored to win Tuesday's NHL matchup [10/28/2025]

NHL action continues on Tuesday at 6:45PM ET as the Columbus Blue Jackets take on the Buffalo Sabres at KeyBank Center.

Based on updated simulations, Dimers' advanced NHL model projects the Sabres as the most likely winner of the Blue Jackets vs. Sabres game.

This article offers a closer look at Tuesday's matchup, including goal scorer projections, best bets and player prop picks.

Blue Jackets vs. Sabres prediction: Who will win, cover the puck line?

Using powerful machine learning and data, we have simulated the outcome of Tuesday's NHL matchup between the Blue Jackets and Sabres 10,000 times as part of our NHL predictions coverage.

Our independent predictive model currently gives the Sabres a 53% chance of defeating the Blue Jackets.

According to our model, the Blue Jackets (+1.5) have a 68% chance of covering the puck line, while the 6.5-goal over/under has a 51% chance of staying under.

Blue Jackets vs. Sabres odds

We have researched the best NHL odds in America for this game, which are listed here:

Bet Type	Blue Jackets	Sabres
Puck Line	+1.5 (-235)	-1.5 (+200)
Moneyline	+100	-120
Total	o6.5 (-102)	u6.5 (-110)

All odds are correct at the time of publication and are subject to change.

Blue Jackets vs. Sabres picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Puck Line	Sabres -1.5	+200
Moneyline	Sabres	-120
Total	Under 6.5	-110

According to our NHL best bets, the top play to make on this game is Under 6.5 total goals.

Blue Jackets vs. Sabres player props

Who will score a goal in Blue Jackets vs. Sabres?

According to our model, Tage Thompson is most likely to score an anytime goal in Blue Jackets vs. Sabres.

Our projections give Thompson a 43.4% chance of scoring a goal at KeyBank Center, while the star is an 8.7% chance of netting the first goal the game.

Anytime goal scorer predictions

Columbus Blue Jackets

Player	Anytime Goal Probability
Kirill Marchenko	33.1%
Adam Fantilli	28.8%
Dmitri Voronkov	28.0%
Kent Johnson	26.1%
Sean Monahan	23.3%

Buffalo Sabres

Player	Anytime Goal Probability
Tage Thompson	43.4%
Alex Tuch	34.7%
Zach Benson	27.9%
Ryan McLeod	23.8%
Jason Zucker	23.6%

First goal scorer predictions

Columbus Blue Jackets

Player	First Goal Probability
Kirill Marchenko	6.7%
Dmitri Voronkov	5.4%
Adam Fantilli	5.3%
Kent Johnson	4.5%
Sean Monahan	3.9%

Buffalo Sabres

Player	First Goal Probability
Tage Thompson	8.7%
Alex Tuch	6.6%
Zach Benson	4.8%
Jason Zucker	3.9%
Jack Quinn	3.8%

Blue Jackets vs. Sabres game-day updates and essential details

Tuesday's game between the Sabres and Blue Jackets at KeyBank Center is scheduled to commence at 6:45PM ET.

• Who: Columbus Blue Jackets vs. Buffalo Sabres
• Date: Tuesday, October 28, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: KeyBank Center

Conclusion

We predict the Sabres, with a 53% win probability, will likely beat the Blue Jackets on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Blue Jackets vs. Sabres insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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