Colorado vs. Illinois prediction: Why Illinois is favored to win women's March Madness First Round matchup [3/21/2026]

Illinois and Colorado will lock horns in women's March Madness First Round action at Memorial Gymnasium on Saturday, starting at 9:30 PM ET.

Based on updated simulation results, Dimers' new women's basketball model predicts Illinois as the most likely winner of the Colorado vs. Illinois game.

This article offers a closer look at Saturday's matchup, including best bets and picks.

Colorado vs. Illinois prediction: Who will win and advance to the Second Round?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAAW Tournament matchup between Colorado and Illinois 10,000 times as part of our women's college basketball predictions coverage.

Our leading predictive model currently gives Illinois a 66% chance of beating Colorado.

According to our model, the over/under total of 132.5 points has a 53% chance of going over.

Colorado vs. Illinois odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Colorado vs. Illinois picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our women's college basketball best bets, the top play to make on this game is Illinois to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Colorado vs. Illinois game-day updates and essential details

Saturday's women's basketball action between Illinois and Colorado at Memorial Gymnasium is scheduled to start at 9:30 PM ET.

• Who: Colorado vs. Illinois
• Date: Saturday, March 21, 2026
• Time: 9:30 PM ET/6:30PM PT
• Venue: Memorial Gymnasium
• March Madness stage: First Round

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Conclusion

We predict Illinois, with a 66% win probability, will likely beat Colorado this women's March Madness First Round matchup.

AI and automation have enhanced this article to quickly deliver accurate Colorado vs. Illinois insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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